I'm not a med sci person, but I bet if we look at the algorithms for getting to large N, all of them are expensive and all of them visit small N first. Anyway t

I'm not a med sci person, but I bet if we look at the algorithms for getting to large N, all of them are expensive and all of them visit small N first. Anyway the results for any N seem very likely to be misleading to laypeople. (Laypeople means "almost everyone." For example I'm in photonics. In psychiatry I'm a layperson.) I agree with nabla's comment that the real problem is our inability as laypeople to properly understand (or even properly upvote) scientific work.