Because you start with a small inexpensive trial first in order to determine whether the larger, more expensive trial is a) safe, and b) worth investing in. Wh

Because you start with a small inexpensive trial first in order to determine whether the larger, more expensive trial is a) safe, and b) worth investing in. What's unfortunate is that the research gets published at this stage beyond the scientific community that understands how inconclusive it is. Because in the long run that just contributes to the erosion of public trust in the scientific method.