3 ms·
Chloroquine is more toxic than Hydrochloroquine, isn't it?
by dionian 7y ago
Chloroquine is more toxic than Hydrochloroquine, isn't it?
- kevingadd 7y agoIIRC the addition of the hydroxy to the drug means it's going to be more water-soluble so it would be easier to excrete in urine and flush it out of the system, which would count as "less toxic" if you squint when reading the paper I haven't seen any detailed discussions of the differences in toxicity, but one physician made a comment to that effect.
- tptacek 7y agoYou probably don't have to derive the relative toxicities axiomatically, since volumes appear to have been written about the lower toxicity of HCQ compared to CQ.