3 ms·

> Chloroquine prevents the virus from affecting hemoglobin This virus attacks the cells that live in the throat and lungs. The "spike" as far as I'm aware does

> Chloroquine prevents the virus from affecting hemoglobin This virus attacks the cells that live in the throat and lungs. The "spike" as far as I'm aware does not attach to haemoglobin. > damage is already done and the hemoglobin is already compromised. Its the lungs that are damaged, not the blood. The reason why people die is because they drown in thier own fluids, as the cells walls of the lungs are broken down by the patient's immune system. If Chloroquine was effective, it would stop the virus reproducing. This would lead to a detectable change in viral load. Sure, it could already be to late by then, the damage is done. But, the viral load would have a measurable change. These studies don't really show anything conclusive. This means that its unlikley to work as a prophylactic as its not actually stopping the virus from attaching or reproducing. > Azithromycin Thats there to stop any opportunistic bacteria from causing more damage. Typically when someone is admitted to ICU for covid they have a lower than expected white cell count. > Antivirals are much more promising yes because they actually disrupt the virus replicating. Chloroquine doesn't appear to do that. This is the problem with making drugs. Something that works in the petridish doesn't always work in the body. This is why Gilead's new wonder drug wasn't in production, because it was designed to target ebola, but didn't really work.

Threeve303 7y ago
> as the cells walls of the lungs are broken down by the patient's immune system If there is actually a real statistical anomaly that Lupus and other immune comprised people are less susceptible to certain parts of the virus, perhaps it's not the medication they take at all. It could simply be that someone who is immune compromised would not have as strong as a reaction as a healthy person and then may actually survive as a result. Less fluid, etc. Also, I am in no way qualified medically, it's just a quarantine showerthought.
- KaiserPro 7y ago
  I have heard of two patients in london who were immuno compromised and recovered quicker than a "normal" person. The real damage occurs when the immune system ramps up to attack the virus, but ends up attacking the cells they are living in as well. Now, most of the time this is fine an normal, but it can also trigger https://en.wikipedia.org/wiki/Cytokine_release_syndrome https://en.wikipedia.org/wiki/Cytokine_release_syndrome which is a nasty feedback loop. There are experiments to give immuno-suppressants at key times to try and limit the damage. But its tricky and dangerous.
rpiguy 7y ago
COVID-19 is not a normal respiratory infection. It seems to prevent your RBCs from holding onto O2 and CO2 mimicking high altitude sickness. The disease acts like HAPE (high altitude pulmonary edema). The damage and inflammation is coming from the blood's inability to properly perform gas exchange in the lungs. Other damage could actually be coming from ventilators with pressure set too high (lungs of patients are mechanically normal, atypical for ARDS). Patient oxygen stats are also weird, they're hypoxic, but not necessarily short of breath. https://vimeo.com/402537849 https://vimeo.com/402537849 https://twitter.com/EricLeeMD/status/1245054768185303041?s=1.. https://twitter.com/EricLeeMD/status/1245054768185303041?s=1.... https://twitter.com/cameronks/status/1243582723945566208?s=1.. https://twitter.com/cameronks/status/1243582723945566208?s=1.... https://www.cureus.com/articles/29004-acetazolamide-nifedipi.. https://www.cureus.com/articles/29004-acetazolamide-nifedipi....

Threeve303 7y ago

> as the cells walls of the lungs are broken down by the patient's immune system If there is actually a real statistical anomaly that Lupus and other immune comprised people are less susceptible to certain parts of the virus, perhaps it's not the medication they take at all. It could simply be that someone who is immune compromised would not have as strong as a reaction as a healthy person and then may actually survive as a result. Less fluid, etc. Also, I am in no way qualified medically, it's just a quarantine showerthought.

KaiserPro 7y ago
I have heard of two patients in london who were immuno compromised and recovered quicker than a "normal" person. The real damage occurs when the immune system ramps up to attack the virus, but ends up attacking the cells they are living in as well. Now, most of the time this is fine an normal, but it can also trigger https://en.wikipedia.org/wiki/Cytokine_release_syndrome https://en.wikipedia.org/wiki/Cytokine_release_syndrome which is a nasty feedback loop. There are experiments to give immuno-suppressants at key times to try and limit the damage. But its tricky and dangerous.

rpiguy 7y ago

COVID-19 is not a normal respiratory infection. It seems to prevent your RBCs from holding onto O2 and CO2 mimicking high altitude sickness. The disease acts like HAPE (high altitude pulmonary edema). The damage and inflammation is coming from the blood's inability to properly perform gas exchange in the lungs. Other damage could actually be coming from ventilators with pressure set too high (lungs of patients are mechanically normal, atypical for ARDS). Patient oxygen stats are also weird, they're hypoxic, but not necessarily short of breath. https://vimeo.com/402537849 https://vimeo.com/402537849 https://twitter.com/EricLeeMD/status/1245054768185303041?s=1.. https://twitter.com/EricLeeMD/status/1245054768185303041?s=1.... https://twitter.com/cameronks/status/1243582723945566208?s=1.. https://twitter.com/cameronks/status/1243582723945566208?s=1.... https://www.cureus.com/articles/29004-acetazolamide-nifedipi.. https://www.cureus.com/articles/29004-acetazolamide-nifedipi....