> If you want to detour into tinfoil hat territory, you could posit that these studies on severe patients were designed knowing it would show low or no efficacy

> If you want to detour into tinfoil hat territory, you could posit that these studies on severe patients were designed knowing it would show low or no efficacy, because it’s too late to protect the patient’s hemoglobin. I would think it is still useful because from what I've read, this protocol is often used for severe cases at the moment, so it's useful to know if it has no impact.