3 ms·
Yeah, I don't know what's the point of these studies that don't look at HCQ+zinc when the hypothesis is that HCQ promotes zinc absorption.
by snapetom 7y ago
Yeah, I don't know what's the point of these studies that don't look at HCQ+zinc when the hypothesis is that HCQ promotes zinc absorption.
- HarryHirsch 7y agoThe hypothesis is that hydroxychloroquin interferes with glycosylation of cell surface proteins that are essential for entry of the virus into the cell. The zinc notion is total bunk, intracellular zinc concentration is tightly controlled. Random zinc excursions just don't happen, if they did they would result in death.
- podgaj 7y agoThis is so wrong I do not know where to start. ADAM17 is responsible for shedding of ACE2 from the cell which creates soluble ACE2. If ACE2 is not ON the cell the virus cannot infect the cell. ADAM17, like ACE2 is a zinc finger protein and uses zinc as a cofactor. Also, zinc is widely understood to lower the immune response by affecting interferon levels. It is not only about intracellular zinc. But in a deficiency intracellular zinc has even less chance of being brought into the cell, right? To say that zinc does not matter because hydroxychloroquin is absurd.
- giardini 7y agoHarryHirsch says "The zinc notion is total bunk..." I am unclear what you mean here but this in-vitro experiment. which studied interaction of zinc ions with chloroquine in a human ovarian cancer cell line. shows far more zinc entering cells that are exposed to chloroquine: "Chloroquine Is a Zinc Ionophore": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/
- pengaru 7y agoIsn't there always going to be some ambient zinc available even without additional supplementing? I imagine there'd be some evidence of efficacy regardless, but this is nowhere near my area of expertise.