4 ms·

https://abc7news.com/amp/coronavirus-drug-covid-19-malaria-hydroxychloroquine/6079864/ https://abc7news.com/amp/coronavirus-drug-covid-19-malaria-h... Not a st

by sdiq 7y ago

https://abc7news.com/amp/coronavirus-drug-covid-19-malaria-hydroxychloroquine/6079864/ https://abc7news.com/amp/coronavirus-drug-covid-19-malaria-h... Not a study but just another anecdote. Using zinc this time round rather than azithromycin.

snapetom 7y ago
Yeah, I don't know what's the point of these studies that don't look at HCQ+zinc when the hypothesis is that HCQ promotes zinc absorption.
- HarryHirsch 7y ago
  The hypothesis is that hydroxychloroquin interferes with glycosylation of cell surface proteins that are essential for entry of the virus into the cell. The zinc notion is total bunk, intracellular zinc concentration is tightly controlled. Random zinc excursions just don't happen, if they did they would result in death.
  - podgaj 7y ago
    This is so wrong I do not know where to start. ADAM17 is responsible for shedding of ACE2 from the cell which creates soluble ACE2. If ACE2 is not ON the cell the virus cannot infect the cell. ADAM17, like ACE2 is a zinc finger protein and uses zinc as a cofactor. Also, zinc is widely understood to lower the immune response by affecting interferon levels. It is not only about intracellular zinc. But in a deficiency intracellular zinc has even less chance of being brought into the cell, right? To say that zinc does not matter because hydroxychloroquin is absurd.
  - giardini 7y ago
    HarryHirsch says "The zinc notion is total bunk..." I am unclear what you mean here but this in-vitro experiment. which studied interaction of zinc ions with chloroquine in a human ovarian cancer cell line. shows far more zinc entering cells that are exposed to chloroquine: "Chloroquine Is a Zinc Ionophore": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/
- pengaru 7y ago
  Isn't there always going to be some ambient zinc available even without additional supplementing? I imagine there'd be some evidence of efficacy regardless, but this is nowhere near my area of expertise.
klipt 7y ago
I hate the way this drug has been politicized by Trump yapping it up before there were any good studies. Politicians should shut up about unproven medicines and leave it to the professionals to actually practice, you know, evidence based medicine.
- betterunix2 7y ago
  "Politicians should shut up and leave it to the professionals" FTFY.
  - giardini 7y ago
    A political leader's role is not to choose medications but to give people hope and to keep the wheels of society rolling. But no matter what, there will always be more questions about what will be done. I think Trump was sufficiently vague yet optimistic in his answers, as befits his role. Consider how different it would have been had he said "We know of nothing that works against this virus." or even worse, "We're screwed! Go home and tell your children we're all gonna die!".

by sdiq 7y ago

snapetom 7y ago

Yeah, I don't know what's the point of these studies that don't look at HCQ+zinc when the hypothesis is that HCQ promotes zinc absorption.

HarryHirsch 7y ago
The hypothesis is that hydroxychloroquin interferes with glycosylation of cell surface proteins that are essential for entry of the virus into the cell. The zinc notion is total bunk, intracellular zinc concentration is tightly controlled. Random zinc excursions just don't happen, if they did they would result in death.
- podgaj 7y ago
  This is so wrong I do not know where to start. ADAM17 is responsible for shedding of ACE2 from the cell which creates soluble ACE2. If ACE2 is not ON the cell the virus cannot infect the cell. ADAM17, like ACE2 is a zinc finger protein and uses zinc as a cofactor. Also, zinc is widely understood to lower the immune response by affecting interferon levels. It is not only about intracellular zinc. But in a deficiency intracellular zinc has even less chance of being brought into the cell, right? To say that zinc does not matter because hydroxychloroquin is absurd.
- giardini 7y ago
  HarryHirsch says "The zinc notion is total bunk..." I am unclear what you mean here but this in-vitro experiment. which studied interaction of zinc ions with chloroquine in a human ovarian cancer cell line. shows far more zinc entering cells that are exposed to chloroquine: "Chloroquine Is a Zinc Ionophore": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/
pengaru 7y ago
Isn't there always going to be some ambient zinc available even without additional supplementing? I imagine there'd be some evidence of efficacy regardless, but this is nowhere near my area of expertise.

klipt 7y ago

I hate the way this drug has been politicized by Trump yapping it up before there were any good studies. Politicians should shut up about unproven medicines and leave it to the professionals to actually practice, you know, evidence based medicine.

betterunix2 7y ago
"Politicians should shut up and leave it to the professionals" FTFY.
- giardini 7y ago
  A political leader's role is not to choose medications but to give people hope and to keep the wheels of society rolling. But no matter what, there will always be more questions about what will be done. I think Trump was sufficiently vague yet optimistic in his answers, as befits his role. Consider how different it would have been had he said "We know of nothing that works against this virus." or even worse, "We're screwed! Go home and tell your children we're all gonna die!".