3 ms·
There's a growing body of evidence that C19 attacks hemoglobin in the blood, with the effects similar to malaria (where the parasite uses hemoglobin as a nutri
by m0zg 7y ago
There's a growing body of evidence that C19 attacks hemoglobin in the blood, with the effects similar to malaria (where the parasite uses hemoglobin as a nutrient source): blood with depleted hemoglobin simply can't carry as much oxygen, so people start gasping for air, their lungs swell, and then pneumonia kills them. Crucially, gasping for air seems to happen well before the onset of pneumonia. This also explains why diabetics are more severely affected.
If that's the case, ventilators aren't going to help if you use air in them, without supplemental oxygen: even if you pump air into the patient's lungs, their blood simply won't be able to carry sufficient oxygen. You need to supplement with oxygen.
It also explains why (hydroxy)chloroquine helps: if it stops/reduces depletion of hemoglobin (which it does [*]), the patient may never progress to pneumonia, because their blood is able to carry sufficient oxygen.
For those who already have pneumonia, supplemental oxygen would be vital if they also have C19. Standard ARDS treatment protocol will not work well.
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf...