6 ms·

There is a paper circulating that claims that the virus impedes red blood cells leading to organ failure including lungs, and not the other way round.

bryanrasmussen 7y ago
so if it impedes red blood cells does this mean my gout is helping me out?
- tejtm 7y ago
  Could you explain the gout - bloodcell - lung damage connection to a non clinician? (me)
  - bryanrasmussen 7y ago
    well actually it's only some sorts of gout, caused by Polycythemia Vera https://rarediseases.org/rare-diseases/polycythemia-vera/ https://rarediseases.org/rare-diseases/polycythemia-vera/ "Gout and kidney stone associated with polycythemia vera occur due to the high turnover of red blood cells, which results in higher-than-normal uric acid production." So it overproduces red blood cells, and the parent comment said there was a theory covid-19 was causing a decrease in red blood cell production so I conjured the amusing scenario in my head of the two diseases fighting each other. An amusing, non-serious, scenario.
    - tejtm 7y ago
      I ask because I was recently doing background checks on a substance to mitigate nitric oxide induced lung damage (produced by damaged cells) which would work by by converting it to urea ... so maybe more than just amusing. and for you https://monarchinitiative.org/disease/MONDO:0005571 https://monarchinitiative.org/disease/MONDO:0005571
nanl2053 7y ago
Do you have a link?
- friedegg 7y ago
  https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf... Among the speculation is that a blood transfusion may be a viable treatment.
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- war1025 7y ago
  This is the other article I saw cited. https://www.cureus.com/articles/29004-acetazolamide-nifedipine-and-phosphodiesterase-inhibitors-rationale-for-their-utilization-as-adjunctive-countermeasures-in-the-treatment-of-coronavirus-disease-2019-covid-19?fbclid=IwAR2QEEkdUBUzd8Yt9VYF03pfoEcyGrTpd8WI1EA3b0amUr-6BXBQPfC_o8Y https://www.cureus.com/articles/29004-acetazolamide-nifedipi...
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wbl 7y ago
That paper uses computer models of protein interactions not actual ethyrocyte on vero 6 cultured COVID experiment. It's an interesting line of investigation but I want to see more in vitro and ideally in vivo findings supporting that before I believe it.
- war1025 7y ago
  It seems super shaky right now, but it's definitely something I'd like to see investigated further.
yread 7y ago
Yeah, it's simulating protein-protein interaction. Very much bleeding edge of research, stuff like this needs biological validation before you should trust it.

bryanrasmussen 7y ago

so if it impedes red blood cells does this mean my gout is helping me out?

tejtm 7y ago
Could you explain the gout - bloodcell - lung damage connection to a non clinician? (me)
- bryanrasmussen 7y ago
  well actually it's only some sorts of gout, caused by Polycythemia Vera https://rarediseases.org/rare-diseases/polycythemia-vera/ https://rarediseases.org/rare-diseases/polycythemia-vera/ "Gout and kidney stone associated with polycythemia vera occur due to the high turnover of red blood cells, which results in higher-than-normal uric acid production." So it overproduces red blood cells, and the parent comment said there was a theory covid-19 was causing a decrease in red blood cell production so I conjured the amusing scenario in my head of the two diseases fighting each other. An amusing, non-serious, scenario.
  - tejtm 7y ago
    I ask because I was recently doing background checks on a substance to mitigate nitric oxide induced lung damage (produced by damaged cells) which would work by by converting it to urea ... so maybe more than just amusing. and for you https://monarchinitiative.org/disease/MONDO:0005571 https://monarchinitiative.org/disease/MONDO:0005571

nanl2053 7y ago

Do you have a link?

friedegg 7y ago
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf... Among the speculation is that a blood transfusion may be a viable treatment.
- deleted 7y ago
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war1025 7y ago
This is the other article I saw cited. https://www.cureus.com/articles/29004-acetazolamide-nifedipine-and-phosphodiesterase-inhibitors-rationale-for-their-utilization-as-adjunctive-countermeasures-in-the-treatment-of-coronavirus-disease-2019-covid-19?fbclid=IwAR2QEEkdUBUzd8Yt9VYF03pfoEcyGrTpd8WI1EA3b0amUr-6BXBQPfC_o8Y https://www.cureus.com/articles/29004-acetazolamide-nifedipi...

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wbl 7y ago

That paper uses computer models of protein interactions not actual ethyrocyte on vero 6 cultured COVID experiment. It's an interesting line of investigation but I want to see more in vitro and ideally in vivo findings supporting that before I believe it.

war1025 7y ago
It seems super shaky right now, but it's definitely something I'd like to see investigated further.

yread 7y ago

Yeah, it's simulating protein-protein interaction. Very much bleeding edge of research, stuff like this needs biological validation before you should trust it.