4 ms·

There's a trial[1] whose objective is to determine if chloroquine is actually useful early on in the infection. With a target sample size of 3000 individuals i

There's a trial[1] whose objective is to determine if chloroquine is actually useful early on in the infection. With a target sample size of 3000 individuals it would have at least sufficient numbers to show if it's actually viable, helps a little, or does not help at all. [1] https://clinicaltrials.gov/ct2/show/NCT04308668?term=hydroxychloroquine&recrs=ab&cond=COVID-19&draw=2 https://clinicaltrials.gov/ct2/show/NCT04308668?term=hydroxy...

theologic 7y ago
I'm also looking forward to this study. Kudos to U of M to get this kicked off quickly. I find it interesting to see how fast they were able to marshal a response. Basically, we go from nothing to something started in 10 days. I've been reflecting on how western culture does not seem as effective as China in suppression of the disease, but the west's ability to do "start up" type activity is amazing, and a place for hope. https://www.twincities.com/2020/03/18/preventing-coronavirus-u-of-m-seeks-1500-volunteers-who-have-been-exposed-to-try-anti-malarial-drug/ https://www.twincities.com/2020/03/18/preventing-coronavirus...
brutt 7y ago
Also,in France: https://www.mediterranee-infection.com/covid-19/ https://www.mediterranee-infection.com/covid-19/
- tonfa 7y ago
  Tho they've focused mostly on care instead of the science (they don't believe in randomized trials), and it's going to be hard to know if the treatment is efficient from those (the EU and Michigan studies should help figuring that out).
  - vanniv 7y ago
    In the absence of other viable treatments, the efficiency isn't really important. Frankly, if it is only modestly effective, it should still be given to everyone without contraindications. Efficiency only becomes important in a year or two when there are competing therapies. When the choices are Chloroquine or Hopes and Prayers, Chloroquine is the obvious choice (for those that don't have the contraindications, of course -- for those patients, you'd need more evidence to know that the benefits outweighed the risks)
RabbitmqGuy 7y ago
The WHO also has a multi country trial that consists of a combo of the four most promising drugs; https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments# https://www.sciencemag.org/news/2020/03/who-launches-global-...

theologic 7y ago

I'm also looking forward to this study. Kudos to U of M to get this kicked off quickly. I find it interesting to see how fast they were able to marshal a response. Basically, we go from nothing to something started in 10 days. I've been reflecting on how western culture does not seem as effective as China in suppression of the disease, but the west's ability to do "start up" type activity is amazing, and a place for hope. https://www.twincities.com/2020/03/18/preventing-coronavirus-u-of-m-seeks-1500-volunteers-who-have-been-exposed-to-try-anti-malarial-drug/ https://www.twincities.com/2020/03/18/preventing-coronavirus...

brutt 7y ago

Also,in France: https://www.mediterranee-infection.com/covid-19/ https://www.mediterranee-infection.com/covid-19/

tonfa 7y ago
Tho they've focused mostly on care instead of the science (they don't believe in randomized trials), and it's going to be hard to know if the treatment is efficient from those (the EU and Michigan studies should help figuring that out).
- vanniv 7y ago
  In the absence of other viable treatments, the efficiency isn't really important. Frankly, if it is only modestly effective, it should still be given to everyone without contraindications. Efficiency only becomes important in a year or two when there are competing therapies. When the choices are Chloroquine or Hopes and Prayers, Chloroquine is the obvious choice (for those that don't have the contraindications, of course -- for those patients, you'd need more evidence to know that the benefits outweighed the risks)

RabbitmqGuy 7y ago

The WHO also has a multi country trial that consists of a combo of the four most promising drugs; https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments# https://www.sciencemag.org/news/2020/03/who-launches-global-...