3 ms·

Double blind peer reviewed trials are a good goal but in the middle of a crisis you can't let a desire for perfection get in the way of the good. There is enoug

Double blind peer reviewed trials are a good goal but in the middle of a crisis you can't let a desire for perfection get in the way of the good. There is enough imperfect evidence that this treatment stack (that is, several drugs used in combination with hydroxychloroquine) has benefits that it should be considered a potential part of a solution. Waiting a couple of years for perfect studies to be carefully conducted is waiting until the crisis is over and the treatment moot. What is well known are the side effects of this drug, their likelyhood, and how to ameliorate them.

gus_massa 7y ago
> There is enough imperfect evidence that this treatment stack [...] has benefits that it should be considered a potential part of a solution. Is there any evidence? Do you have a link to the best evidence so far? Did someone tried a similar treatment and get the same result? It is not necessary to have a perfect study, because there too little time. But how hard is to make a study with a randomized control group? You are not sure if this drug is better or worse, so giving only the standard treatment perhaps is better. I guess a double blind experiment is more difficult for logistic reasons, but if the patients have respirators and are sedated, it is almost a single blind experiment. And if the results are the number of death or an analysis in a lab by a machine (instead of self reports), they can be less influenceable.
- brutt 7y ago
  See there: https://www.mediterranee-infection.com/covid-19/ https://www.mediterranee-infection.com/covid-19/
- pbreit 7y ago
  Yes, there is quite a bit of evidence. Proven against SARS in vitro: https://www.ncbi.nlm.nih.gov/pubmed/15351731 https://www.ncbi.nlm.nih.gov/pubmed/15351731 And much evidence for efficacy against COVID-19 in humans: https://twitter.com/__ice9/status/1246549028382408706 https://twitter.com/__ice9/status/1246549028382408706

gus_massa 7y ago

> There is enough imperfect evidence that this treatment stack [...] has benefits that it should be considered a potential part of a solution. Is there any evidence? Do you have a link to the best evidence so far? Did someone tried a similar treatment and get the same result? It is not necessary to have a perfect study, because there too little time. But how hard is to make a study with a randomized control group? You are not sure if this drug is better or worse, so giving only the standard treatment perhaps is better. I guess a double blind experiment is more difficult for logistic reasons, but if the patients have respirators and are sedated, it is almost a single blind experiment. And if the results are the number of death or an analysis in a lab by a machine (instead of self reports), they can be less influenceable.

brutt 7y ago
See there: https://www.mediterranee-infection.com/covid-19/ https://www.mediterranee-infection.com/covid-19/
pbreit 7y ago
Yes, there is quite a bit of evidence. Proven against SARS in vitro: https://www.ncbi.nlm.nih.gov/pubmed/15351731 https://www.ncbi.nlm.nih.gov/pubmed/15351731 And much evidence for efficacy against COVID-19 in humans: https://twitter.com/__ice9/status/1246549028382408706 https://twitter.com/__ice9/status/1246549028382408706