I'll try to explain below. Monoclonal antibodies, or mAb are made usually by fusing a right B cell or splicing a gene sequence for the right light chains (V, D

I'll try to explain below. Monoclonal antibodies, or mAb are made usually by fusing a right B cell or splicing a gene sequence for the right light chains (V, D) into a leukemic cancer cell line producing a so called hybridoma. Those cells are damaged in such a way as to produce tons of antibodies and are immortal. By using a different starter cell line you can get different antibody classes. Also by providing a different interleukin stimulus to the cells. Typically IgG is made because it's easiest, but there are options. See: https://www.sciencedirect.com/science/article/abs/pii/S0022175915001246?via%3Dihub https://www.sciencedirect.com/science/article/abs/pii/S00221... Here's a helpful blog post: https://www.tebu-bio.com/blog/2018/11/13/monoclonal-antibodies-all-you-need-to-know-about-antibody-generation/ https://www.tebu-bio.com/blog/2018/11/13/monoclonal-antibodi...