5 ms·

Article is here: https://advances.sciencemag.org/content/6/14/eaay9095 https://advances.sciencemag.org/content/6/14/eaay9095 Earlier work is described in the U

Article is here: https://advances.sciencemag.org/content/6/14/eaay9095 https://advances.sciencemag.org/content/6/14/eaay9095 Earlier work is described in the U of I press release: https://mechanical.illinois.edu/news/force-triggers-gene-expression-stretching-chromatin https://mechanical.illinois.edu/news/force-triggers-gene-exp... and available to read here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121013/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121013/ Glad that none of the work was behind paywall!

vanderZwan 7y ago
> Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation I'm sure it's common knowledge to people inside the field, but "The weak power law" is quite vague for non-experts. From the article I got this: > In this study, we reveal that high force frequency (>50 Hz) does not induce rapid transcription, although the chromatin is being stretched to sufficient extents to allow for transcription. Over the last two decades, studies on the rheological responses of living cells demonstrate that living cells exhibit a gradual stiffening response to increasing force frequencies [i.e., the weak power law (12, 27)]. Ok, that doesn't really clarify that much for me. Is it the (weak power) law or the weak (power law), for example? I mean we're talking about exerting force, both kind of could make sense. Any experts willing to explain a bit?
- kens 7y ago
  You got me curious. Apparently it's "weak power-law" and means a power-law relationship only applies over part of the range. As opposed to strong power law which applies over the full curve, or false power law where only a truncated part of the data fits a power law. Different types of power laws: https://arxiv.org/pdf/1507.03408.pdf https://arxiv.org/pdf/1507.03408.pdf Power-law rheology of cells: https://www.annualreviews.org/doi/pdf/10.1146/annurev-matsci-062910-100351 https://www.annualreviews.org/doi/pdf/10.1146/annurev-matsci...
  - vanderZwan 7y ago
    Thank you for looking it up!

vanderZwan 7y ago

> Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation I'm sure it's common knowledge to people inside the field, but "The weak power law" is quite vague for non-experts. From the article I got this: > In this study, we reveal that high force frequency (>50 Hz) does not induce rapid transcription, although the chromatin is being stretched to sufficient extents to allow for transcription. Over the last two decades, studies on the rheological responses of living cells demonstrate that living cells exhibit a gradual stiffening response to increasing force frequencies [i.e., the weak power law (12, 27)]. Ok, that doesn't really clarify that much for me. Is it the (weak power) law or the weak (power law), for example? I mean we're talking about exerting force, both kind of could make sense. Any experts willing to explain a bit?

kens 7y ago
You got me curious. Apparently it's "weak power-law" and means a power-law relationship only applies over part of the range. As opposed to strong power law which applies over the full curve, or false power law where only a truncated part of the data fits a power law. Different types of power laws: https://arxiv.org/pdf/1507.03408.pdf https://arxiv.org/pdf/1507.03408.pdf Power-law rheology of cells: https://www.annualreviews.org/doi/pdf/10.1146/annurev-matsci-062910-100351 https://www.annualreviews.org/doi/pdf/10.1146/annurev-matsci...
- vanderZwan 7y ago
  Thank you for looking it up!