3 ms·
>> A recent study in humans demonstrated that B. burgdorferi DNA was identified in PTDLS patient by xenodiagnosis but unable to culture viable spirochete17. In
by James_Henry 7y ago
>> A recent study in humans demonstrated that B. burgdorferi DNA was identified in PTDLS patient by xenodiagnosis but unable to culture viable spirochete17. In about 85% of Lyme arthritis patients, B. burgdorferi DNA was detected in synovial fluid by polymerase chain reaction (PCR) testing
The previous sentence is also important:
>Many research studies has [sic] shown that B. burgdorferi establishes persistent infections after antibiotic treatment in various animal models.
- PragmaticPulp 7y agoI'll review the citations in this study once again, but the evidence for lingering spirochetes in humans is always thin. Much of it relies on indirect testing that is difficult to replicate or prone to laboratory errors. I'd love to be completely wrong and for this to be a game-changing solution, but after years of following this research I'm suspicious of the idea that persistent yet mysteriously undetectable (in humans) spirochetes are responsible for PTLSD symptoms.
- wolco 7y agoThe idea of lingering unwanted resistant bacteria not being killed by antibiotics have been shown true with other spore type bacteria. I don't have the background in this specific bacteria, why do you believe it would be so different?
- loeg 7y agoIt seems like their opinion is informed on the basis of the existing scientific evidence, which is eminently reasonable, IMO.
- power 7y agoI'm interested in your opinion of the citations too. They purport to show persistence beyond standard treatment in mice, dogs, macaques and humans, the latter via xenodiagnosis and PCR. PCR is pretty direct.