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>To me this raises the question of whether clinical trials are really even possible right now in the first place, or whether making decisions based off in vitro
by James_Henry 7y ago
>To me this raises the question of whether clinical trials are really even possible right now in the first place, or whether making decisions based off in vitro data is the best we can do for right now.
I don't think I understand this. We have a clinical trial with in vivo data right here though, right?
- Alex3917 7y ago> We have a clinical trial with in vivo data right here though, right? AFAIK there's no clinical trial data, but there is in vivo data. My point though is that these are drugs that block viral replication, and we're mostly only administering them after the virus has already finished replicating. So in that scenario of course it's going to look ineffective regardless of whether it actually works or not. I don't believe the data showing it works, but I also don't believe the data showing it doesn't work.
- James_Henry 7y agoWhen you say clinical trial, what are you meaning? I think the usual definition would include this paper as a clinical trial. Do you mean the FDA hasn't overseen any clinical trials? Also, why don't you believe the data? or is it the conclusions that the researchers draw from the data that you don't believe? The statistics and trial design in this paper seem to be sound.