I sometimes use NetBSD's pkgsrc on macOS because it installs super cleanly in any prefix you like and never, ever breaks the system. It doesn't have everything,

I sometimes use NetBSD's pkgsrc on macOS because it installs super cleanly in any prefix you like and never, ever breaks the system. It doesn't have everything, and you will occasionally encounter a package that won't build, but it doesn't even dream of taking over /usr/local or disrupting your system. You could install it into your home directory if you wanted to (which I have done, on systems where I don't have root or enough ownership to just throw things anywhere)