While the general sentiment and advice you give is mostly correct, I feel like adding my two cents from my experience -- as a person who occasionally publishes

While the general sentiment and advice you give is mostly correct, I feel like adding my two cents from my experience -- as a person who occasionally publishes in these sorts of journals. In my opinion, you have the Science/Nature thing vs their spinoff exactly the other way around. Science/Nature only publish flashy things more for their "memeness" value than their actual scientific content. The first driver leading you to those journal is how much the paper can be talked about and picked up by other media outlets. In fact, the most important thing you need to publish in Science/Nature is NOT a good experiment/result, but being a coauthor of somebody who already has a lot of Science/Nature papers. Their spinoffs, on the other hand, being less driven by popularity, often offer more solid content.