I don't think the perfect happiness drug causes you to sit inside and end your life quickly. That sounds a lot like heroine, which we already have, and is very

I don't think the perfect happiness drug causes you to sit inside and end your life quickly. That sounds a lot like heroine, which we already have, and is very much not perfect. When I'm happy, I still go out and do things, and the happier I am, the longer I want to live, so I eat healthfully and exercise. The perfect happiness drug would make me want to extend my own life and spread joy to others, so I'd probably still have kids and try to provide for them. If it meanwhile made me give up hopes of winning the Superbowl or founding a unicorn, meh, I'm ok with that. If you stretch the meaning of "ambition" to cover all of "life and civilization" then I think it's not possible to achieve happiness while dropping ambition.