As a non-designer I've used both blueprint and the 960.gs grid system. They both work fine and I've never ran into the problems he describes with either one.

As a non-designer I've used both blueprint and the 960.gs grid system. They both work fine and I've never ran into the problems he describes with either one. My somewhat limited understand of the two is the blueprint addresses issues with typography and sets a typographical rhythm, so it has some advantage there. However, I think it's pretty easy to trash that rhythm if you don't know what you're doing.