3 ms·
Drugs don't spread out evenly through the whole body. For this class of drug, it's bloodstream concentration that matters. The complex field of pharmacokinetic
by tlb 7y ago
Drugs don't spread out evenly through the whole body. For this class of drug, it's bloodstream concentration that matters.
The complex field of pharmacokinetics relates the bloodstream concentration to the ingested amount over time. The simple version uses a "volume of distribution" which, for salicylate, is 11.9 liters for a standard male. [https://sepia.unil.ch/pharmacology/index.php?id=83 https://sepia.unil.ch/pharmacology/index.php?id=83].
So to achieve the 1 - 7 milimolar concentrations they used would require 3.8 - 27.2 grams of aspirin.
- epmaybe 7y agoThis kills the kidneys
- leereeves 7y agoWhat's the half-life of aspirin in the bloodstream? Probably less than a day, which would significantly increase the dose required to maintain those concentrations. It seems like this might merit further research as a treatment for severe cases, but it's far too dangerous to be a prophylactic for healthy people. (And that's all assuming these results on other coronaviruses apply to the new coronavirus that causes COVID-19.)
- lavi_luffy 7y agohi