To be more precise: 50 millimolar was the stock concentration, not the concentration used in the experiments. The effective concentrations were between 1 and 7

To be more precise: 50 millimolar was the stock concentration, not the concentration used in the experiments. The effective concentrations were between 1 and 7 millimolar. > The results indicate an effective concentration 50 (EC50) of 1.31 mM for HCoV-229E resulting in a selectivity index (SI: CC50/IC50) of 15.6 as well as an EC50 of 3.69 mM for MERS-CoV, leading to an SI of 15.9, similar to that of HCoV-229E (Figures 2D and 2E). The EC50 for HCoV-229E-infected PBMCs at 24 h was 6.71 mM resulting in an SI of 5.7 (Figure 2F). And if tlb is right that the volume of distribution is under 12 liters, the dose required in the best case would be approximately the maximum dose of aspirin (4 grams). In the worst case, far more.