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> Nevermind the fact that in vitro tests usually use concentrations that would never be achieved in the body, a fact usually lost on the public. But the reason
by Alex3917 7y ago
> Nevermind the fact that in vitro tests usually use concentrations that would never be achieved in the body, a fact usually lost on the public.
But the reason large doses are used in vitro is because it's easier to show that a chemical actually inhibits viral replication if you can slow down replication by 99.9%. But in real life, you might only need to slow down replication by 10% or whatever to meaningfully improve clinical outcomes.
- JohnJamesRambo 7y agoThat's true in theory and we should see aspirin doing something in vivo for coronavirus if it did, but we don't. Something else more important seems to be affecting it the other way. In skimming the article it seems they used 20 mM doses and ranges which is an absolutely enormous amount of anything. We normally considered low uM the range where something is even beginning to be interesting.