3 ms·
Please don't parrot conspiracy theories. The virus shares almost 100% of its identity with known pangolin viruses. > The discovery of multiple lineages of pang
by f38zf5vdt 7y ago
Please don't parrot conspiracy theories. The virus shares almost 100% of its identity with known pangolin viruses.
> The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of novel coronaviruses and should be removed from wet markets to prevent zoonotic transmission.
https://www.nature.com/articles/s41586-020-2169-0 https://www.nature.com/articles/s41586-020-2169-0
Edit: To clarify, these viruses have approximately 90% identity but in the (oft-suspected and brought up) ACE2-binding spike protein there is a ~97% sequence identity.
> In particular, SARS-CoV-2 exhibits very high sequence similarity to the Guangdong pangolin coronaviruses in the receptor-binding domain (RBD; 97.4%) ... Indeed, the Guangdong pangolin coronaviruses and SARS-CoV-2 possess identical amino acids at the five critical residues of the RBD.
There is another preprint that details more about betacoronavirus recombination.
https://www.biorxiv.org/content/10.1101/2020.02.10.942748v1.full.pdf https://www.biorxiv.org/content/10.1101/2020.02.10.942748v1....
It's almost certainly the product of a recombination event between a pangolin and bat betacoronavirus, since recombination aggressively involves the spike protein in betacoronaviruses. Since we already have a bat virus with high identity (96%) and now a spike protein with very high identity (97%), both in the same phylogenetic tree with origins to SARS-CoV-2, it's reasonably to assume that this is the product of natural recombinant evolution.
Now, it might be the case that it's guided evolution in a Wuhan lab somewhere, but I don't really buy it. Nature is staggeringly good at producing new and innovating viruses, and I believe we will soon find more closely related ancestors to this virus.
- tropo 7y agoWe know, from published scientific research in well-respected journals, that "guided evolution in a Wuhan lab somewhere" has been happening for many years. We also know that China has previously had several terrifying biocontainment failures with virus labs. Things got out, including coronaviruses, but were stopped before spreading far and wide. By the way, the very original conspiracy theory was eventually proven correct. Calling it a conspiracy theory was a great way to mock people who were pointing out the truth.