5 ms·

Sorry, this is just not true. The in-vitro results for chloroquine as an antiviral have been positive for many viruses, but it has never worked out in RCTs. C

by et2o 7y ago

Sorry, this is just not true. The in-vitro results for chloroquine as an antiviral have been positive for many viruses, but it has never worked out in RCTs. Claiming there is good evidence from in-vivo studies is scientifically illiterate. Please post links to well-done RCTs if you believe they exist. There is a reason the WHO is running a 5-arm clinical trial for COVID. Edit: Your response to me literally says “In-Vitro” in the title. Edit 2: “There is absolutely evidence” ... But no links. No, sorry, you are still just wrong.

deleted 7y ago
[deleted]
pbreit 7y ago
There is absolutely evidence of effectiveness against COVID-19 in humans from China, South Korea & France.
- et2o 7y ago
  Please let me and the CDC know of these well-conducted trials of chloroquine for COVID. I take it you are not familiar with epidemiology, clinical evaluation of drug efficacy, or medical statistics. That’s fine! No one is saying you need to be. But you shouldn’t be extremely confident of your conclusions when experts are telling you that you’re wrong. The French chloroquine+azithromycin trial was terrible and no one in the medical world believes it. There’s a reason no respectable journal would publish it. SIX of the people in the C+A arm died and were removed from the analysis, which is absurd. The outcome was viral titers, which were different for different arms. Just maddening.
  - gus_massa 7y ago
    I agree. Nitpicking: I think only 1 person in the treatment group died. It is not clear that the 3 that were transferred to the ICU finally died. (And 1 just left the hospital and 1 had too much nausea with the drugs, I hope that at least they are fine.)
    - et2o 7y ago
      You are exactly right. I was remembering wrong.
  - pbreit 7y ago
    One died. I am not extremely confident in what is not even a conclusion. I am simply shocked at the pushback and resistance to a promising treatment with minimal downsides. Medecine appears to be the only profession in the world that only accepts one form of evidence. That is what is maddening.

by et2o 7y ago

deleted 7y ago

[deleted]

pbreit 7y ago

There is absolutely evidence of effectiveness against COVID-19 in humans from China, South Korea & France.

et2o 7y ago
Please let me and the CDC know of these well-conducted trials of chloroquine for COVID. I take it you are not familiar with epidemiology, clinical evaluation of drug efficacy, or medical statistics. That’s fine! No one is saying you need to be. But you shouldn’t be extremely confident of your conclusions when experts are telling you that you’re wrong. The French chloroquine+azithromycin trial was terrible and no one in the medical world believes it. There’s a reason no respectable journal would publish it. SIX of the people in the C+A arm died and were removed from the analysis, which is absurd. The outcome was viral titers, which were different for different arms. Just maddening.
- gus_massa 7y ago
  I agree. Nitpicking: I think only 1 person in the treatment group died. It is not clear that the 3 that were transferred to the ICU finally died. (And 1 just left the hospital and 1 had too much nausea with the drugs, I hope that at least they are fine.)
  - et2o 7y ago
    You are exactly right. I was remembering wrong.
- pbreit 7y ago
  One died. I am not extremely confident in what is not even a conclusion. I am simply shocked at the pushback and resistance to a promising treatment with minimal downsides. Medecine appears to be the only profession in the world that only accepts one form of evidence. That is what is maddening.