3 ms·

Almost no one should be taking 4g of acetaminophen a day. That’s definitely going to be toxic given enough time. It doesn’t belong in convo with other drugs be

by et2o 7y ago

Almost no one should be taking 4g of acetaminophen a day. That’s definitely going to be toxic given enough time. It doesn’t belong in convo with other drugs because it requires far less monitoring. It’s also not taken chronically like the other drugs. Or shouldn’t be, at least.

Johnny555 7y ago
Maybe they shouldn't, but isn't that kind of the whole problem with overdose? People take a higher dose than they should? Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year.Data from the U.S. Acute Liver Failure Study Group registry of more than 700 patients with acute liver failure across the United States implicates acetaminophen poisoning in nearly 50% of all acute liver failure in this country. Available in many single or combination products, acetaminophen produces more than 1 billion US dollars in annual sales for Tylenol products alone. It is heavily marketed for its safety compared to nonsteroidal analgesics. By enabling self-diagnosis and treatment of minor aches and pains, its benefits are said by the Food and Drug Administration to outweigh its risks. It still must be asked: Is this amount of injury and death really acceptable for an over-the-counter pain reliever? https://www.ncbi.nlm.nih.gov/pubmed/15239078 https://www.ncbi.nlm.nih.gov/pubmed/15239078
- et2o 7y ago
  I have lost track of the point of this conversation. If you think acetaminophen is qualitatively the same as warfarin or lithium, you need to go to med school.
refurb 7y ago
4g of acetaminophen is what you'd take if you followed the directions of an adult taking 2 regular strength tablets every 4 hours for 24 hours (3.9g to be exact).
- et2o 7y ago
  I understand that. That said, any physician who sees a patient taking 4g of acetaminophen a day chronically is going to tell them to reduce their dosage, switch to another drug, or stop. It’s not safe in the long run.

by et2o 7y ago

Johnny555 7y ago

Maybe they shouldn't, but isn't that kind of the whole problem with overdose? People take a higher dose than they should? Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year.Data from the U.S. Acute Liver Failure Study Group registry of more than 700 patients with acute liver failure across the United States implicates acetaminophen poisoning in nearly 50% of all acute liver failure in this country. Available in many single or combination products, acetaminophen produces more than 1 billion US dollars in annual sales for Tylenol products alone. It is heavily marketed for its safety compared to nonsteroidal analgesics. By enabling self-diagnosis and treatment of minor aches and pains, its benefits are said by the Food and Drug Administration to outweigh its risks. It still must be asked: Is this amount of injury and death really acceptable for an over-the-counter pain reliever? https://www.ncbi.nlm.nih.gov/pubmed/15239078 https://www.ncbi.nlm.nih.gov/pubmed/15239078

et2o 7y ago
I have lost track of the point of this conversation. If you think acetaminophen is qualitatively the same as warfarin or lithium, you need to go to med school.

refurb 7y ago

4g of acetaminophen is what you'd take if you followed the directions of an adult taking 2 regular strength tablets every 4 hours for 24 hours (3.9g to be exact).

et2o 7y ago
I understand that. That said, any physician who sees a patient taking 4g of acetaminophen a day chronically is going to tell them to reduce their dosage, switch to another drug, or stop. It’s not safe in the long run.