4 ms·

The FDA approved emergency expanded access for inhaled nitric oxide a couple days ago, which has the same mechanism of action as garlic and beet root. There is

The FDA approved emergency expanded access for inhaled nitric oxide a couple days ago, which has the same mechanism of action as garlic and beet root. There is actually a plausible mechanism of action there, and a bunch of in vitro research.

throwaway_pdp09 7y ago
Post a link because I right now I have no reason to believe you.
- Alex3917 7y ago
  I posted links to one of the in vitro studies here, and in the comments I posted the press release for the FDA approval: https://www.reddit.com/r/covid19stack https://www.reddit.com/r/covid19stack
  - throwaway_pdp09 7y ago
    This goes to "COVID-19 Stack: Research and discussion on supplements and medications relating to COVID-19! No mate, post a precise link. This one goes nowhere and I still don't believe you.
  - et2o 7y ago
    Your information is wrong and misleading. It’s irresponsible for you to post stuff like this.
    - deleted 7y ago
      [deleted]
- deleted 7y ago
  [deleted]
- HarryHirsch 7y ago
  He probably means this: https://www.fiercebiotech.com/medtech/fda-expands-access-to-bellerophon-s-nitric-oxide-gas-for-covid-19-lung-symptoms https://www.fiercebiotech.com/medtech/fda-expands-access-to-... But that has nothing to do with HIV, neither do garlic and beetroot have anything to do with nitric oxide.
  - Alex3917 7y ago
    > neither do garlic and beetroot have anything to do with nitric oxide. "Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications." https://www.ncbi.nlm.nih.gov/pubmed/7555034 https://www.ncbi.nlm.nih.gov/pubmed/7555034 ...
    - throwaway_pdp09 7y ago
      Validated at least by reference, which he has given. Upvoted. We need more than this such as references to it or disclaimers for it, niether of which I can find. That is not to detract from the existence of the paper which he referenced. Whether nitric oxide has much to do with health is anothre question. I believe one of the reasons viagra works is due to nitric oxide, so perhaps it's we should be viagring instead.
      - AstralStorm 7y ago
        Mind you the important part is where it's enhanced, and by how much. And we're taking purified alicin at nearly toxic doses. In vitro. Yes, garlic can kill. And it was described to be active in vascular tissue not lungs. Now Viagra is an interesting bet, but it also does not reach lungs or non-vascular cells.
      - deleted 7y ago
        [deleted]
maxerickson 7y ago
For treatment of HIV? Other poster is apparently talking about https://en.wikipedia.org/wiki/HIV/AIDS_denialism_in_South_Africa https://en.wikipedia.org/wiki/HIV/AIDS_denialism_in_South_Af...
- Alex3917 7y ago
  > For treatment of HIV? For any virus. I didn't say it was safe or effective, I said there is a plausible mechanism of action.
  - HarryHirsch 7y ago
    You got that wrong. Nitric oxide is a vasodilator, it relaxes smooth muscles in the blood vessels and lungs to increase blood and air flow. It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate.
    - Alex3917 7y ago
      > It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate. "Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus" https://jvi.asm.org/content/79/3/1966 https://jvi.asm.org/content/79/3/1966 ...
      - AstralStorm 7y ago
        Nitric oxide ion in cell is not the same as nitrous oxide gas, typically used for sedation, not taking NO itself. Enhancing NO signaling in cells is hard. The best initial bet there would be using certain class of beta-blockers. (Ones typically used for black patients.) But please do not take unproven drugs with known side effects. The paper is talking about S-nitroso-N-acetylpenicillamine in vitro. This compound is not something anyone wants to actually take.
et2o 7y ago
This is insane. Garlic and beet root are not used medically for any disease at all, let alone COVID. NO evidence is pretty weak for COVID. Even if it was true, we’d give NO or other related compounds and certainly not unregulated dietary supplements.
- Alex3917 7y ago
  > Garlic and beet root are not used medically for any disease at all Garlic is literally one of the most widely used medical treatments in the entire world. It's used medically by 0.8% of all US adults, according to the NIH. https://nccih.nih.gov/research/statistics/NHIS/2012/natural-products/garlic https://nccih.nih.gov/research/statistics/NHIS/2012/natural-... It's use was advocated for my Hippocrates. You know, the "father of medicine" guy. https://academic.oup.com/jn/article/131/3/951S/4687053 https://academic.oup.com/jn/article/131/3/951S/4687053
  - et2o 7y ago
    I can’t tell if this is a troll or not. It is listed below echinacea and cranberry pills (two supplements with substantial evidence for NON-efficacy) on the National Institute for Complementary and Alternative Medicine’s ranking of SUPPLEMENTS taken in the US. If it was real effective medicine, it wouldn’t be considered an “alternative” medicine (a polite phrase for horseshit). Do you realize how ridiculous that is as evidence for anything? The fact that misguided people buy it in supplement form does not mean it is a treatment for anything, let alone COVID. People also buy lots of Diet Coke. And then to top it off you reference Hippocrates (literally thousands of years ago). Did you know most Med schools don’t even take the Hippocratic oath any longer? Do you believe that doctors should treat people by keeping the 4 humors in balance? Completely ridiculous
    - throwaway_pdp09 7y ago
      Reference does not say it's of any use. However it is organic so it must be good.
    - Alex3917 7y ago

throwaway_pdp09 7y ago

Post a link because I right now I have no reason to believe you.

Alex3917 7y ago
I posted links to one of the in vitro studies here, and in the comments I posted the press release for the FDA approval: https://www.reddit.com/r/covid19stack https://www.reddit.com/r/covid19stack
- throwaway_pdp09 7y ago
  This goes to "COVID-19 Stack: Research and discussion on supplements and medications relating to COVID-19! No mate, post a precise link. This one goes nowhere and I still don't believe you.
- et2o 7y ago
  Your information is wrong and misleading. It’s irresponsible for you to post stuff like this.
  - deleted 7y ago
    [deleted]
deleted 7y ago
[deleted]
HarryHirsch 7y ago
He probably means this: https://www.fiercebiotech.com/medtech/fda-expands-access-to-bellerophon-s-nitric-oxide-gas-for-covid-19-lung-symptoms https://www.fiercebiotech.com/medtech/fda-expands-access-to-... But that has nothing to do with HIV, neither do garlic and beetroot have anything to do with nitric oxide.
- Alex3917 7y ago
  > neither do garlic and beetroot have anything to do with nitric oxide. "Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications." https://www.ncbi.nlm.nih.gov/pubmed/7555034 https://www.ncbi.nlm.nih.gov/pubmed/7555034 ...
  - throwaway_pdp09 7y ago
    Validated at least by reference, which he has given. Upvoted. We need more than this such as references to it or disclaimers for it, niether of which I can find. That is not to detract from the existence of the paper which he referenced. Whether nitric oxide has much to do with health is anothre question. I believe one of the reasons viagra works is due to nitric oxide, so perhaps it's we should be viagring instead.
    - AstralStorm 7y ago
      Mind you the important part is where it's enhanced, and by how much. And we're taking purified alicin at nearly toxic doses. In vitro. Yes, garlic can kill. And it was described to be active in vascular tissue not lungs. Now Viagra is an interesting bet, but it also does not reach lungs or non-vascular cells.
    - deleted 7y ago
      [deleted]

maxerickson 7y ago

For treatment of HIV? Other poster is apparently talking about https://en.wikipedia.org/wiki/HIV/AIDS_denialism_in_South_Africa https://en.wikipedia.org/wiki/HIV/AIDS_denialism_in_South_Af...

Alex3917 7y ago
> For treatment of HIV? For any virus. I didn't say it was safe or effective, I said there is a plausible mechanism of action.
- HarryHirsch 7y ago
  You got that wrong. Nitric oxide is a vasodilator, it relaxes smooth muscles in the blood vessels and lungs to increase blood and air flow. It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate.
  - Alex3917 7y ago
    > It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate. "Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus" https://jvi.asm.org/content/79/3/1966 https://jvi.asm.org/content/79/3/1966 ...
    - AstralStorm 7y ago
      Nitric oxide ion in cell is not the same as nitrous oxide gas, typically used for sedation, not taking NO itself. Enhancing NO signaling in cells is hard. The best initial bet there would be using certain class of beta-blockers. (Ones typically used for black patients.) But please do not take unproven drugs with known side effects. The paper is talking about S-nitroso-N-acetylpenicillamine in vitro. This compound is not something anyone wants to actually take.

et2o 7y ago

This is insane. Garlic and beet root are not used medically for any disease at all, let alone COVID. NO evidence is pretty weak for COVID. Even if it was true, we’d give NO or other related compounds and certainly not unregulated dietary supplements.

Alex3917 7y ago
> Garlic and beet root are not used medically for any disease at all Garlic is literally one of the most widely used medical treatments in the entire world. It's used medically by 0.8% of all US adults, according to the NIH. https://nccih.nih.gov/research/statistics/NHIS/2012/natural-products/garlic https://nccih.nih.gov/research/statistics/NHIS/2012/natural-... It's use was advocated for my Hippocrates. You know, the "father of medicine" guy. https://academic.oup.com/jn/article/131/3/951S/4687053 https://academic.oup.com/jn/article/131/3/951S/4687053
- et2o 7y ago
  I can’t tell if this is a troll or not. It is listed below echinacea and cranberry pills (two supplements with substantial evidence for NON-efficacy) on the National Institute for Complementary and Alternative Medicine’s ranking of SUPPLEMENTS taken in the US. If it was real effective medicine, it wouldn’t be considered an “alternative” medicine (a polite phrase for horseshit). Do you realize how ridiculous that is as evidence for anything? The fact that misguided people buy it in supplement form does not mean it is a treatment for anything, let alone COVID. People also buy lots of Diet Coke. And then to top it off you reference Hippocrates (literally thousands of years ago). Did you know most Med schools don’t even take the Hippocratic oath any longer? Do you believe that doctors should treat people by keeping the 4 humors in balance? Completely ridiculous
  - throwaway_pdp09 7y ago
    Reference does not say it's of any use. However it is organic so it must be good.
  - Alex3917 7y ago