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Can anyone comment about the worldwide production capacity and possible lower price limits for these drugs? It should be possible to supply a large part of the

Can anyone comment about the worldwide production capacity and possible lower price limits for these drugs? It should be possible to supply a large part of the worlds population with (hydroxy)chloroquinine if that is deemed a solution, but the others seem less ideal candidates for that, or am I wrong?

rscho 7y ago
What I can personally comment on is that if people go on with hoarding on quinine derivatives, we're gonna have a massive problem whether it's found effective or not. The hoarding is even happening among my lesser scientifically-reasonable md colleagues. This has to stop. Now.
- matsemann 7y ago
  Norwegian doctors have also been hoarding this for themselves lately. Enough that the Norwegian government had to step in and put it on a list so those that actually need it day-to-day can get hold of it. I hope when this is over, someone will look into this behaviour from the MDs. It's eroding trust in the system when they claim potentially vital resources for themselves.
  - nickthemagicman 7y ago
    Not to mention have a government enforced monopoly on it.
  - rscho 7y ago
    Note that given the dismissive behaviour of Occidental medical leaders regarding covid, I wonder what's left of trust in the system. Our bosses were still laughing at us for worrying on Monday evening, and now they're pissing their pants. Idiots.
  - XaspR8d 7y ago
    I don't know what the situation is like in Norway, but I 100% don't blame MDs in the US for trying to find their own treatments, because they're generally being left high and dry by the extreme rationing of the PPE. Doctors themselves have taken to personally reaching out to the communities near me so that they can find masks. Obviously I don't want anyone with lupus / malaria / etc to be adversely affected, but I think the people being forced to work the front lines do deserve to be somehow prioritized just from a "how do we keep the system operating efficiently" standpoint, and it doesn't really seem like the people who could manage supplies to make sure both parties needs are balanced, e.g. hospital administrations and regional governments, are going to take much responsibility for that.
  - rscho 7y ago
    When this is over, what we absolutely have to look into is the generational conflict. <50yo: all MDs understand and have been vocal about it for weeks. >50yo: nah, this can't happen to us great minds. Let's start preparing when the first patients are already in the ICU.
- thesimp 7y ago
  Hoarding is only a part of the problem. A company in The Netherlands producing chloroquine has got 24/7 police protection as of this weekend because some people came to them and were very insistent that they would like to have some product. Link in dutch: https://eenvandaag.avrotros.nl/item/fabrikant-van-coronamedicijn-bedreigd-ik-kreeg-steeds-vaker-vage-types-op-bezoek/ https://eenvandaag.avrotros.nl/item/fabrikant-van-coronamedi...
- beamatronic 7y ago
  Would drinking tonic water help?
  - compiler-guy 7y ago
    Modern tonic water contains substantially less quinine than the tonic waters that were used to fight, say, cholera in the historical period. So, yes, if we lived in India in the mid-to-late 1800s, drinking tonic water might help, at least for the things that quinine helps. But modern tonic water isn't really anything like that. https://en.wikipedia.org/wiki/Tonic_water https://en.wikipedia.org/wiki/Tonic_water
Alex3917 7y ago
Before the virus, the global supply of Remdesivir was only enough to treat a few hundred people. Chloroquine and Hydroxychloroquine are apparently very easy to make, and can be scaled up very quickly. Not sure about the last two. Regardless, WHO should be doing trials on more over-the-counter products. It's dumb that they put out a statement warning people that there was no evidence that Garlic could be used as an antiviral, despite the fact that literally two days ago the FDA granted emergency expanded access for some multi-million dollar inhaled nitric oxide device based on the fact that nitric oxide has been shown to block the replication of SARS-CoV in vitro. (Guess the mechanism of action by which eating raw garlic nearly instantly lowers your blood pressure.) Sources here: https://www.reddit.com/r/covid19stack/ https://www.reddit.com/r/covid19stack/
- throwanem 7y ago
  You're not telling the full story. That approval was for compassionate use, i.e. it can be used in patients who are already in grave danger of death, because at that point it can't hurt and there's nothing known to have a chance of helping anyway. And the article you're referencing chooses to link press releases, but only vaguely mention studies not only without linking but without even providing enough information to identify them - which hardly inspires confidence. And the subreddit from which you're getting it is...wow. Just an absolute heap of fear-driven misinformation, and while I'm not without compassion for the people there who feel the urge to do something to protect themselves in the face of a very frightening situation, it's important to try to keep a clear enough head to understand the difference between developing knowledge and multiplying tiny probabilities into meaningless, misleading rumors. That subreddit is doing the second one of those, not the first. For the sake of your own emotional wellbeing, please consider taking it less seriously. edit: Oh, sorry, I hadn't noticed that the people posting in that subreddit are basically 90% you. So, I guess I'm warning everybody else off it, and asking you to consider doing less of this, in the cause of everyone else's emotional wellbeing.
  - deleted 7y ago
    [deleted]
  - 7y ago

rscho 7y ago

What I can personally comment on is that if people go on with hoarding on quinine derivatives, we're gonna have a massive problem whether it's found effective or not. The hoarding is even happening among my lesser scientifically-reasonable md colleagues. This has to stop. Now.

matsemann 7y ago
Norwegian doctors have also been hoarding this for themselves lately. Enough that the Norwegian government had to step in and put it on a list so those that actually need it day-to-day can get hold of it. I hope when this is over, someone will look into this behaviour from the MDs. It's eroding trust in the system when they claim potentially vital resources for themselves.
- nickthemagicman 7y ago
  Not to mention have a government enforced monopoly on it.
- rscho 7y ago
  Note that given the dismissive behaviour of Occidental medical leaders regarding covid, I wonder what's left of trust in the system. Our bosses were still laughing at us for worrying on Monday evening, and now they're pissing their pants. Idiots.
- XaspR8d 7y ago
  I don't know what the situation is like in Norway, but I 100% don't blame MDs in the US for trying to find their own treatments, because they're generally being left high and dry by the extreme rationing of the PPE. Doctors themselves have taken to personally reaching out to the communities near me so that they can find masks. Obviously I don't want anyone with lupus / malaria / etc to be adversely affected, but I think the people being forced to work the front lines do deserve to be somehow prioritized just from a "how do we keep the system operating efficiently" standpoint, and it doesn't really seem like the people who could manage supplies to make sure both parties needs are balanced, e.g. hospital administrations and regional governments, are going to take much responsibility for that.
- rscho 7y ago
  When this is over, what we absolutely have to look into is the generational conflict. <50yo: all MDs understand and have been vocal about it for weeks. >50yo: nah, this can't happen to us great minds. Let's start preparing when the first patients are already in the ICU.
thesimp 7y ago
Hoarding is only a part of the problem. A company in The Netherlands producing chloroquine has got 24/7 police protection as of this weekend because some people came to them and were very insistent that they would like to have some product. Link in dutch: https://eenvandaag.avrotros.nl/item/fabrikant-van-coronamedicijn-bedreigd-ik-kreeg-steeds-vaker-vage-types-op-bezoek/ https://eenvandaag.avrotros.nl/item/fabrikant-van-coronamedi...
beamatronic 7y ago
Would drinking tonic water help?
- compiler-guy 7y ago
  Modern tonic water contains substantially less quinine than the tonic waters that were used to fight, say, cholera in the historical period. So, yes, if we lived in India in the mid-to-late 1800s, drinking tonic water might help, at least for the things that quinine helps. But modern tonic water isn't really anything like that. https://en.wikipedia.org/wiki/Tonic_water https://en.wikipedia.org/wiki/Tonic_water

Alex3917 7y ago

Before the virus, the global supply of Remdesivir was only enough to treat a few hundred people. Chloroquine and Hydroxychloroquine are apparently very easy to make, and can be scaled up very quickly. Not sure about the last two. Regardless, WHO should be doing trials on more over-the-counter products. It's dumb that they put out a statement warning people that there was no evidence that Garlic could be used as an antiviral, despite the fact that literally two days ago the FDA granted emergency expanded access for some multi-million dollar inhaled nitric oxide device based on the fact that nitric oxide has been shown to block the replication of SARS-CoV in vitro. (Guess the mechanism of action by which eating raw garlic nearly instantly lowers your blood pressure.) Sources here: https://www.reddit.com/r/covid19stack/ https://www.reddit.com/r/covid19stack/

throwanem 7y ago
You're not telling the full story. That approval was for compassionate use, i.e. it can be used in patients who are already in grave danger of death, because at that point it can't hurt and there's nothing known to have a chance of helping anyway. And the article you're referencing chooses to link press releases, but only vaguely mention studies not only without linking but without even providing enough information to identify them - which hardly inspires confidence. And the subreddit from which you're getting it is...wow. Just an absolute heap of fear-driven misinformation, and while I'm not without compassion for the people there who feel the urge to do something to protect themselves in the face of a very frightening situation, it's important to try to keep a clear enough head to understand the difference between developing knowledge and multiplying tiny probabilities into meaningless, misleading rumors. That subreddit is doing the second one of those, not the first. For the sake of your own emotional wellbeing, please consider taking it less seriously. edit: Oh, sorry, I hadn't noticed that the people posting in that subreddit are basically 90% you. So, I guess I'm warning everybody else off it, and asking you to consider doing less of this, in the cause of everyone else's emotional wellbeing.
- deleted 7y ago
  [deleted]
- 7y ago