4 ms·

Do you have a source for the last part?

rscho 7y ago
This doesn't need a source. It's common clinical knowledge and OP is right. Unfortunately, preliminary results using our usual immunomodulatory drugs have been catastrophic.
- ajross 7y ago
  No, sorry, you still need a source. In fact cytokine storms aren't the only driver of pneumonia and we don't know yet exactly what the mechanism(s) behind ARDS is. Immunology is outrageously complicated, and not well suited to that kind of pronouncement. You just have to do the science, there's no way around it. And realistically we may not have time.
  - rscho 7y ago
    I will reformulate, then. In the current state of knowledge about both ARDS and Covid and given the time available, clinicians rely on traditional teachings to care for covid-related ARDS until solid evidence can be provided.
hnrodey 7y ago
Last night I watched a YouTube video about COVID-19 symptoms and stages of the disease and it did touch on the points brought up by OP.
- agumonkey 7y ago
  Could you share the url ?
  - stamps 7y ago
    Maybe OP is referring to this one? https://www.youtube.com/watch?v=BtN-goy9VOY https://www.youtube.com/watch?v=BtN-goy9VOY
  - ayoubElk 7y ago
    Not GP but this video gives a good overview: https://www.youtube.com/watch?v=BtN-goy9VOY https://www.youtube.com/watch?v=BtN-goy9VOY
  - hnrodey 7y ago
    This is specifically the video I watched yesterday. https://www.youtube.com/watch?v=OOJqHPfG7pA https://www.youtube.com/watch?v=OOJqHPfG7pA
    - agumonkey 7y ago
      oh I should have guessed :) if you want some interesting details from American MDs there's this podcast http://www.microbe.tv/twiv/twiv-593/ http://www.microbe.tv/twiv/twiv-593/ lots of subtle details that you can't get on simplified stats
mathgeek 7y ago
Not OP, but here's a Lancet correspondence on the topic (includes references): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
DocSavage 7y ago
A good synopsis of current understanding (as of last Friday) was a UCSF Medicine Grand Rounds broadcast. I've bookmarked the most relevant slide to our discussion in particular: https://youtu.be/bt-BzEve46Y?t=2349 https://youtu.be/bt-BzEve46Y?t=2349 Significant lung and myocardial injury and papers have honed in on ARDS as a real problem.
- bluenose69 7y ago
  This is a wonderful resource. Thank you for pointing it out.

This doesn't need a source. It's common clinical knowledge and OP is right. Unfortunately, preliminary results using our usual immunomodulatory drugs have been catastrophic.

ajross 7y ago
No, sorry, you still need a source. In fact cytokine storms aren't the only driver of pneumonia and we don't know yet exactly what the mechanism(s) behind ARDS is. Immunology is outrageously complicated, and not well suited to that kind of pronouncement. You just have to do the science, there's no way around it. And realistically we may not have time.
- rscho 7y ago
  I will reformulate, then. In the current state of knowledge about both ARDS and Covid and given the time available, clinicians rely on traditional teachings to care for covid-related ARDS until solid evidence can be provided.

hnrodey 7y ago

Last night I watched a YouTube video about COVID-19 symptoms and stages of the disease and it did touch on the points brought up by OP.

agumonkey 7y ago
Could you share the url ?
- stamps 7y ago
  Maybe OP is referring to this one? https://www.youtube.com/watch?v=BtN-goy9VOY https://www.youtube.com/watch?v=BtN-goy9VOY
- ayoubElk 7y ago
  Not GP but this video gives a good overview: https://www.youtube.com/watch?v=BtN-goy9VOY https://www.youtube.com/watch?v=BtN-goy9VOY
- hnrodey 7y ago
  This is specifically the video I watched yesterday. https://www.youtube.com/watch?v=OOJqHPfG7pA https://www.youtube.com/watch?v=OOJqHPfG7pA
  - agumonkey 7y ago
    oh I should have guessed :) if you want some interesting details from American MDs there's this podcast http://www.microbe.tv/twiv/twiv-593/ http://www.microbe.tv/twiv/twiv-593/ lots of subtle details that you can't get on simplified stats

mathgeek 7y ago

Not OP, but here's a Lancet correspondence on the topic (includes references): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

DocSavage 7y ago

A good synopsis of current understanding (as of last Friday) was a UCSF Medicine Grand Rounds broadcast. I've bookmarked the most relevant slide to our discussion in particular: https://youtu.be/bt-BzEve46Y?t=2349 https://youtu.be/bt-BzEve46Y?t=2349 Significant lung and myocardial injury and papers have honed in on ARDS as a real problem.

bluenose69 7y ago
This is a wonderful resource. Thank you for pointing it out.