3 ms·
This drug has actually been mentioned in several past clinical studies on the closely-related SARS. The particular study below has been circulating in several a
by chasil 7y ago
This drug has actually been mentioned in several past clinical studies on the closely-related SARS. The particular study below has been circulating in several areas online, and has citations to several more:
https://cmr.asm.org/content/20/4/660.long https://cmr.asm.org/content/20/4/660.long
Despite the role of the pH-sensitive endosomal protease cathepsin L in the entry pathway (151, 300), viral culture does not require pretreatment with trypsin. However, this pH-sensitive cathepsin L may be a target for agents such as chloroquine, which elevates endosomal pH (174, 341).
- hanniabu 7y agoI'm sure I'm not the only one wondering this..... what does this mean in layman's terms?
- treis 7y agoThe chemical pathway that allows the virus to enter the cell changes based on the pH of the cell. Chloroquine changes the pH of that pathway and therefore may slow/stop the entry of the virus into the cell.