4 ms·

Bear in mind in relation to immunity -- "Positive results may be due to past or present infection with non-SARS-CoV-2 coronavirus strains, such as coronavirus H

Bear in mind in relation to immunity -- "Positive results may be due to past or present infection with non-SARS-CoV-2 coronavirus strains, such as coronavirus HKU1, NL63, OC43, or 229E."

teruakohatu 7y ago
Slightly off topic question: do people who have been infected with those varieties have any sort of immunity against covid-19?
- Aperocky 7y ago
  Potentially. If true, we might rush to get everyone cold and then be immune to coronavirus.
- teddyvangogh 7y ago
  No immunity. but they develop antibodies. More info here: "FDA is working on treatment of coronavirus with blood from recovered patients" "The method — essentially harvesting virus-fighting antibodies from the blood of previously infected patients — dates back more than a century" https://www.nbcnews.com/health/health-news/fda-working-treatment-coronavirus-blood-recovered-patients-n1165231 https://www.nbcnews.com/health/health-news/fda-working-treat...
- hedora 7y ago
  Some health professional floated the theory that kids aren’t getting it as much as the rest of the population because they’ve recently been hammered with all the coronaviruses at daycare. I’m hoping this is true, since it suggests new parents are mostly OK too.
  - ummonk 7y ago
    I keep searching for animal studies on this and come up empty - all I can find is some studies on serological cross response when testing people for SARS exposure. Vaccines are obviously the best bet, but I wonder whether deliberately exposing the healthy to common cold Coronavirus might improve herd immunity against this Coronavirus. E.g. maybe in late summer it can be used to forestall a second wave of Coronavirus spread in the winter.
    - freeone3000 7y ago
      Do it like we did smallpox? Worth a shot...
  - yokaze 7y ago
    The theory I've heard: Children mostly rely on their innate immune system compared to adults, where the adaptive immune system is more fully developed. In elderly people, the immune response of both systems is slower/weaker.
calvinmorrison 7y ago
Those are the most common corona viruses strains that cause symptoms of the common cold (which itself is caused by something like ~200 known different viruses, the most prevelant being rhinoviruses). I was under the impression many people already had these antibodies
acqq 7y ago
From the last paragraph before conclusion of their article: "Certainly, this test cannot confirm virus presence, only provide evidence of recent infection, but it provides an important immunological evidence for physicians to make the correct diagnosis along with other tests and to start treatment of patients. In addition, possible cross-reactivity with other coronaviruses and flu viruses were not studied, and the change level of antibody was not compared in the different stages of SARS-CoV-2 infection."
absherwin 7y ago
This preprint explores, in part, cross-reactivity for a similar test and found it to negligible: https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v1.full.pdf https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v...

Bear in mind in relation to immunity -- "Positive results may be due to past or present infection with non-SARS-CoV-2 coronavirus strains, such as coronavirus HKU1, NL63, OC43, or 229E."

teruakohatu 7y ago

Slightly off topic question: do people who have been infected with those varieties have any sort of immunity against covid-19?

Aperocky 7y ago
Potentially. If true, we might rush to get everyone cold and then be immune to coronavirus.
teddyvangogh 7y ago
No immunity. but they develop antibodies. More info here: "FDA is working on treatment of coronavirus with blood from recovered patients" "The method — essentially harvesting virus-fighting antibodies from the blood of previously infected patients — dates back more than a century" https://www.nbcnews.com/health/health-news/fda-working-treatment-coronavirus-blood-recovered-patients-n1165231 https://www.nbcnews.com/health/health-news/fda-working-treat...
hedora 7y ago
Some health professional floated the theory that kids aren’t getting it as much as the rest of the population because they’ve recently been hammered with all the coronaviruses at daycare. I’m hoping this is true, since it suggests new parents are mostly OK too.
- ummonk 7y ago
  I keep searching for animal studies on this and come up empty - all I can find is some studies on serological cross response when testing people for SARS exposure. Vaccines are obviously the best bet, but I wonder whether deliberately exposing the healthy to common cold Coronavirus might improve herd immunity against this Coronavirus. E.g. maybe in late summer it can be used to forestall a second wave of Coronavirus spread in the winter.
  - freeone3000 7y ago
    Do it like we did smallpox? Worth a shot...
- yokaze 7y ago
  The theory I've heard: Children mostly rely on their innate immune system compared to adults, where the adaptive immune system is more fully developed. In elderly people, the immune response of both systems is slower/weaker.

calvinmorrison 7y ago

Those are the most common corona viruses strains that cause symptoms of the common cold (which itself is caused by something like ~200 known different viruses, the most prevelant being rhinoviruses). I was under the impression many people already had these antibodies

acqq 7y ago

From the last paragraph before conclusion of their article: "Certainly, this test cannot confirm virus presence, only provide evidence of recent infection, but it provides an important immunological evidence for physicians to make the correct diagnosis along with other tests and to start treatment of patients. In addition, possible cross-reactivity with other coronaviruses and flu viruses were not studied, and the change level of antibody was not compared in the different stages of SARS-CoV-2 infection."

absherwin 7y ago

This preprint explores, in part, cross-reactivity for a similar test and found it to negligible: https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v1.full.pdf https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v...