It might. Historically pandemics have remade the global map and socio-economic system. The combination of WW1 + Spanish Flu led to the collapse of the Russian

It might. Historically pandemics have remade the global map and socio-economic system. The combination of WW1 + Spanish Flu led to the collapse of the Russian, Austrian, Ottoman, and Chinese empires along with the formation of the UK and a resurgent American, German, and Italian nationalism. Black Death led to the collapse of the feudal system and the rise of bourgeoise capitalism. The Plague of Justinian laid to rest any hopes that the Byzantine empire would recapture the Western Roman Empire and lead to a reunified Rome. I could see this being the start of a ~10 year period of social unrest, plague, and natural calamities that eventually destroys the nation-state in favor of a loose conglomeration of city-states.