I don't see a place to put commas that would help. "The Doctor, Who Helped Defeat Smallpox, Explains..." would refer to a subject already introduced, and there

I don't see a place to put commas that would help. "The Doctor, Who Helped Defeat Smallpox, Explains..." would refer to a subject already introduced, and there's no other way to separate "Doctor" and "Who" that I can see.