I can only speak from my own experience, taking it prophylactically while traveling overseas in a malaria prone area. I had to discontinue it after 5 days becau

I can only speak from my own experience, taking it prophylactically while traveling overseas in a malaria prone area. I had to discontinue it after 5 days because it was keeping me from my work: profound, irrational depression, constant cold sweats, painful tinnitus, nausea and disabling fatigue. Perhaps these side effects would have gone away over the long term. Autoimmune diseases, can be way, way worse, particularly arthropathies, since, if unchecked, they cause permanent damage. Also IME, as a rule disease modifying drugs have really nasty side effects. You take them anyway, because you have no better alternative :(