Not a medicinal chemist, but here is an overview of the synthesis routes we know of: https://www.sciencedirect.com/topics/chemistry/chloroquine https://www.sci

Not a medicinal chemist, but here is an overview of the synthesis routes we know of: https://www.sciencedirect.com/topics/chemistry/chloroquine https://www.sciencedirect.com/topics/chemistry/chloroquine From this, it doesn't look like there are any major hurdles in the necessary precursors. E.g. chloroaniline is very commonly used for making many drugs (incl. chlorhexidine), methyl acrylate is similarly in the six-figure-tonnes-per-year category, and that diamine also looks to have a nice synthesis route. Fingers and toes crossed for this one.