3 ms·

I wonder if the U.S is going to use these drugs or if most docs will be too conventional to use these drugs off label. "Antiviral Treatment... lopinavir/ritona

I wonder if the U.S is going to use these drugs or if most docs will be too conventional to use these drugs off label. "Antiviral Treatment... lopinavir/ritonavir (2 capsules, po q12h} combined with arbidol (200 mg po ql 2h)...chloroquine phosphate can be used on adults... Interferon nebulization Darunavir/cobicistat hdarunavir/ cobicistat (1 tablet qd) or favipiravir (starting dose of 1600 mg followed by 600 mg tid) is an alternative option after the ethical review. Simultaneous use of three or more antiviral drugs is not recommended. "

ddeck 7y ago
>I wonder if the U.S is going to use these drugs or if most docs will be too conventional to use these drugs off label. Domestic therapeutic recommendations from a number of European countries (e.g. France, Italy, Switzerland, Belgium) includes use of these medications, so I think it likely they will. e.g. Belgium: https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_InterimGuidelines_Treatment_ENG.pdf https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_In...
- konamicode 7y ago
  Do you know if the other countries you mentioned have equivalent documents to the one you linked for Belgium?
hkai 7y ago
Arbidol is totally fake Russian medicine though, shame on China for falling for the scam.
- est 7y ago
  Yeah I heard that too. It's at most an HA protein inhibitor, while the SARS-CoV-2 likely to bind with ACE2 receptor. Also it requires high concentration of the drug. It's been discussed in China back in Feb. https://www.zhihu.com/question/369651688/answer/998764757 https://www.zhihu.com/question/369651688/answer/998764757 https://zhuanlan.zhihu.com/p/104331976 https://zhuanlan.zhihu.com/p/104331976 https://zhuanlan.zhihu.com/p/105098611 https://zhuanlan.zhihu.com/p/105098611 https://zhuanlan.zhihu.com/p/105309573 https://zhuanlan.zhihu.com/p/105309573 TL;DR it's controversial.

ddeck 7y ago

>I wonder if the U.S is going to use these drugs or if most docs will be too conventional to use these drugs off label. Domestic therapeutic recommendations from a number of European countries (e.g. France, Italy, Switzerland, Belgium) includes use of these medications, so I think it likely they will. e.g. Belgium: https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_InterimGuidelines_Treatment_ENG.pdf https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_In...

konamicode 7y ago
Do you know if the other countries you mentioned have equivalent documents to the one you linked for Belgium?

hkai 7y ago

Arbidol is totally fake Russian medicine though, shame on China for falling for the scam.

est 7y ago
Yeah I heard that too. It's at most an HA protein inhibitor, while the SARS-CoV-2 likely to bind with ACE2 receptor. Also it requires high concentration of the drug. It's been discussed in China back in Feb. https://www.zhihu.com/question/369651688/answer/998764757 https://www.zhihu.com/question/369651688/answer/998764757 https://zhuanlan.zhihu.com/p/104331976 https://zhuanlan.zhihu.com/p/104331976 https://zhuanlan.zhihu.com/p/105098611 https://zhuanlan.zhihu.com/p/105098611 https://zhuanlan.zhihu.com/p/105309573 https://zhuanlan.zhihu.com/p/105309573 TL;DR it's controversial.