4 ms·

2 days ago, UK government was still recommending Ibuprofen. A few days before that, I had aready found some info that NSAIDs should be avoided if you have Coron

by tomp 7y ago

2 days ago, UK government was still recommending Ibuprofen. A few days before that, I had aready found some info that NSAIDs should be avoided if you have CoronaVirus, and you should be taking Paracetamol instead. I’ll take my “influencers” any day, thank you very much!

mattkrause 7y ago
Is there any /solid/ data on that? I've seen the short Lancet piece which speculates about co-morbidities and an ACE-related mechanism, but the text is explicitly very speculative.
- raphlinus 7y ago
  I've been following this. It was mentioned by Anthony Fauci in his JAMA interview this morning. The WHO is recommending against ibuprofen, but primarily out of caution. There is weak empirical support for the caution, but it doesn't look like a big deal; there are vastly more important things to worry about right now, but this is one of those things that spreads really fast through social media, probably largely because it's easy to understand. Good survey I found: https://www.sciencemediacentre.org/expert-reaction-to-reports-that-the-french-health-minister-recommended-use-of-paracetamol-for-fever-from-covid-19-rather-than-ibuprofen-or-cortisone/ https://www.sciencemediacentre.org/expert-reaction-to-report...
- tomp 7y ago
  French Ministry of Health tweeting that is solid enough for me. But feel free to wait for scientific paper in 18 months!
  - mattkrause 7y ago
    It certainly makes sense as a precaution, but I'm surprised how widely this advice has spread. As near as I can tell, it's based on a) 4 sicker-than-expected youth who were taking NSAIDs b) a difficult-to-disentangle association and c) a plausible but by no means ironclad mechanism.
    - tomp 7y ago
      There's a difference between a void of evidence because there's little (or no) effect, vs. a void of evidence because the potential causal factor (and observations of it) (in this case: novel coronavirus) hasn't been present long enough to allow more/better evidence.
wool_gather 7y ago
This is a textbook example of confirmation bias. (And that's assuming the paracetamol thing is even correct.)

by tomp 7y ago

mattkrause 7y ago

Is there any /solid/ data on that? I've seen the short Lancet piece which speculates about co-morbidities and an ACE-related mechanism, but the text is explicitly very speculative.

raphlinus 7y ago
I've been following this. It was mentioned by Anthony Fauci in his JAMA interview this morning. The WHO is recommending against ibuprofen, but primarily out of caution. There is weak empirical support for the caution, but it doesn't look like a big deal; there are vastly more important things to worry about right now, but this is one of those things that spreads really fast through social media, probably largely because it's easy to understand. Good survey I found: https://www.sciencemediacentre.org/expert-reaction-to-reports-that-the-french-health-minister-recommended-use-of-paracetamol-for-fever-from-covid-19-rather-than-ibuprofen-or-cortisone/ https://www.sciencemediacentre.org/expert-reaction-to-report...
tomp 7y ago
French Ministry of Health tweeting that is solid enough for me. But feel free to wait for scientific paper in 18 months!
- mattkrause 7y ago
  It certainly makes sense as a precaution, but I'm surprised how widely this advice has spread. As near as I can tell, it's based on a) 4 sicker-than-expected youth who were taking NSAIDs b) a difficult-to-disentangle association and c) a plausible but by no means ironclad mechanism.
  - tomp 7y ago
    There's a difference between a void of evidence because there's little (or no) effect, vs. a void of evidence because the potential causal factor (and observations of it) (in this case: novel coronavirus) hasn't been present long enough to allow more/better evidence.

wool_gather 7y ago

This is a textbook example of confirmation bias. (And that's assuming the paracetamol thing is even correct.)