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Reinfection could not occur in SARS-CoV-2 infected rhesus macaques "In this study, our results indicated that the primary SARS-CoV-2 infection could protect fr

by JanSt 7y ago

Reinfection could not occur in SARS-CoV-2 infected rhesus macaques "In this study, our results indicated that the primary SARS-CoV-2 infection could protect from subsequent exposures, which have the reference of prognosis of the disease and vital implications for vaccine design.Importantly, the unsuccessful rechallenge in NHP models suggested that the re-positivity from discharged patients could not be due to reinfection. It needs to consider more complicated issues to find out the causes." https://www.biorxiv.org/content/10.1101/2020.03.13.990226v1.full.pdf https://www.biorxiv.org/content/10.1101/2020.03.13.990226v1.... That's a pretty good sign for an equal response in humans.

dwaltrip 7y ago
Looking briefly at the study (I only skimmed the beginning), it seems they attempted the reinfenction quite soon after the recovery from the initial infection. This doesn't tell us anything about how long one may be immune for afterwards. Does anyone have knowledge about the length of periods of immunity (or lack thereof) in various infectious diseases?
- rimliu 7y ago
  IIRC immunity for coronaviruses typicaly is 6months-two years. And I am not sure , but if you get reinfected after that, once you clear the second infection your immunity will last longer yet.
  - dwaltrip 7y ago
    That sounds pretty good! I hope it's true. I was worried it might be much shorter than that.
  - scotty79 7y ago
    So Boris Johnson will just have to re-infect 50% of UK citizens every 6-24 months while perfectly protecting seniors to keep his idea of herd immunity.
    - ajuc 7y ago
      And increase number of hospitals 8 times :)
    - rimliu 7y ago
      Well, the hope is to have vaccine within two years.
scotty79 7y ago
They found them clean 14 days after infection and tried to re-infect them 28 days after initial infection. So immunity lasts at least 14 days after complete recovery. In rhesus macaques who recovered in 14 days.

by JanSt 7y ago

dwaltrip 7y ago

Looking briefly at the study (I only skimmed the beginning), it seems they attempted the reinfenction quite soon after the recovery from the initial infection. This doesn't tell us anything about how long one may be immune for afterwards. Does anyone have knowledge about the length of periods of immunity (or lack thereof) in various infectious diseases?

rimliu 7y ago
IIRC immunity for coronaviruses typicaly is 6months-two years. And I am not sure , but if you get reinfected after that, once you clear the second infection your immunity will last longer yet.
- dwaltrip 7y ago
  That sounds pretty good! I hope it's true. I was worried it might be much shorter than that.
- scotty79 7y ago
  So Boris Johnson will just have to re-infect 50% of UK citizens every 6-24 months while perfectly protecting seniors to keep his idea of herd immunity.
  - ajuc 7y ago
    And increase number of hospitals 8 times :)
  - rimliu 7y ago
    Well, the hope is to have vaccine within two years.

scotty79 7y ago

They found them clean 14 days after infection and tried to re-infect them 28 days after initial infection. So immunity lasts at least 14 days after complete recovery. In rhesus macaques who recovered in 14 days.