The therapeutic window for chloroquine is small, and there are very adverse side-effects if overdosed (heart arrythmias being the most dramatic I guess but macu

The therapeutic window for chloroquine is small, and there are very adverse side-effects if overdosed (heart arrythmias being the most dramatic I guess but macular toxicity is not something you'd want to risk either). I actually heard a story on that's how they dosed it "back in the days" - the sailors took it until they fainted our of various heart arrythmias and then they knew they had to back down a bit next time..