5 ms·

The Lancet has published a study this week that anti-inflamatory drugs may help Ncovid penetrate cell walls and actually speed up the process. France has stopp

by ArnoVW 7y ago

The Lancet has published a study this week that anti-inflamatory drugs may help Ncovid penetrate cell walls and actually speed up the process. France has stopped over-the-counter sales of Ibuprofen as of mid January. https://www.afrinik.com/anti-inflammatory-drugs-can-make-coronavirus-infection-worse/ https://www.afrinik.com/anti-inflammatory-drugs-can-make-cor...

IAmGraydon 7y ago
Not only anti inflammatory drugs but also ACE inhibitors used to treat hypertension.
woodpanel 7y ago
This has been disputed: "This speculation about the safety of ACE-i or ARB treatment in relation to COVID-19 does not have a sound scientific basis or evidence to support it. Indeed, there is evidence from studies in animals suggesting that these medications might be rather protective against serious lung complications in patients with COVID-19 infection, but to date there is no data in humans. The Council on Hypertension of the European Society of Cardiology wish to highlight the lack of any evidence supporting harmful effect of ACE-I and ARB in the context of the pandemic COVID-19 outbreak. The Council on Hypertension strongly recommend that physicians and patients should continue treatment with their usual anti-hypertensive therapy because there is no clinical or scientific evidence to suggest that treatment with ACEi or ARBs should be discontinued because of the Covid-19 infection. " [1] There are also the brilliant MedCram updates, where the issue of ace inhibitors et. al just happened to be discussed yesterday. In it he describes the mechanics of ACE-i and ARB treatment: https://www.youtube.com/watch?v=1vZDVbqRhyM https://www.youtube.com/watch?v=1vZDVbqRhyM [1] https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/position-statement-of-the-esc-council-on-hypertension-on-ace-inhibitors-and-ang https://www.escardio.org/Councils/Council-on-Hypertension-(C...
- DagAgren 7y ago
  That is not actually a refutation.
  - woodpanel 7y ago
    Not a native speaker, but refutation to me translates to disputed… anyways edited for clarity.
    - tridentlead 7y ago
      To dispute something usually just means to disagree with it. Refutation generally implies positive evidence that a position is wrong.
    - DagAgren 7y ago
      Yeah, disputed is much better.
- learc83 7y ago
  The GP was talking about NSAIDS and you're posting about blood pressure medicine. There are similarities, but still.
darkerside 7y ago
Not familiar with afrinik, but this has been reported in The Guardian https://www.theguardian.com/world/2020/mar/16/health-experts-criticise-nhs-advice-to-take-ibuprofen-for-covid-19 https://www.theguardian.com/world/2020/mar/16/health-experts...
khafra 7y ago
The Lancet article was not a study, it was a "correspondence," an educated guess from a researcher. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2...
- vikramkr 7y ago
  I don't know if it's more responsible for the researchernto ouvlish their educated guess immediately - it's perhaps more likely than not to be right based on their expertise and they truley believe it's a really issue and might feel obligated to talk about it. Or, if it's more responsible to do the work first and get some preliminary evidence. Those few days during the pandemic could be crucial for rapid response, and if there's a strong rationale for it maybe it's worth communicating, but this isn't like "it can spread in xyz manner" that really changes behavior - you still be have to do social distancing whether or not Advil makes you more susceptible -is the panic that your painkiller will give you the coronavirus worth it?

by ArnoVW 7y ago

IAmGraydon 7y ago

Not only anti inflammatory drugs but also ACE inhibitors used to treat hypertension.

woodpanel 7y ago

This has been disputed: "This speculation about the safety of ACE-i or ARB treatment in relation to COVID-19 does not have a sound scientific basis or evidence to support it. Indeed, there is evidence from studies in animals suggesting that these medications might be rather protective against serious lung complications in patients with COVID-19 infection, but to date there is no data in humans. The Council on Hypertension of the European Society of Cardiology wish to highlight the lack of any evidence supporting harmful effect of ACE-I and ARB in the context of the pandemic COVID-19 outbreak. The Council on Hypertension strongly recommend that physicians and patients should continue treatment with their usual anti-hypertensive therapy because there is no clinical or scientific evidence to suggest that treatment with ACEi or ARBs should be discontinued because of the Covid-19 infection. " [1] There are also the brilliant MedCram updates, where the issue of ace inhibitors et. al just happened to be discussed yesterday. In it he describes the mechanics of ACE-i and ARB treatment: https://www.youtube.com/watch?v=1vZDVbqRhyM https://www.youtube.com/watch?v=1vZDVbqRhyM [1] https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/position-statement-of-the-esc-council-on-hypertension-on-ace-inhibitors-and-ang https://www.escardio.org/Councils/Council-on-Hypertension-(C...

DagAgren 7y ago
That is not actually a refutation.
- woodpanel 7y ago
  Not a native speaker, but refutation to me translates to disputed… anyways edited for clarity.
  - tridentlead 7y ago
    To dispute something usually just means to disagree with it. Refutation generally implies positive evidence that a position is wrong.
  - DagAgren 7y ago
    Yeah, disputed is much better.
learc83 7y ago
The GP was talking about NSAIDS and you're posting about blood pressure medicine. There are similarities, but still.

darkerside 7y ago

Not familiar with afrinik, but this has been reported in The Guardian https://www.theguardian.com/world/2020/mar/16/health-experts-criticise-nhs-advice-to-take-ibuprofen-for-covid-19 https://www.theguardian.com/world/2020/mar/16/health-experts...

khafra 7y ago

The Lancet article was not a study, it was a "correspondence," an educated guess from a researcher. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2...

vikramkr 7y ago
I don't know if it's more responsible for the researchernto ouvlish their educated guess immediately - it's perhaps more likely than not to be right based on their expertise and they truley believe it's a really issue and might feel obligated to talk about it. Or, if it's more responsible to do the work first and get some preliminary evidence. Those few days during the pandemic could be crucial for rapid response, and if there's a strong rationale for it maybe it's worth communicating, but this isn't like "it can spread in xyz manner" that really changes behavior - you still be have to do social distancing whether or not Advil makes you more susceptible -is the panic that your painkiller will give you the coronavirus worth it?