> Quinine is one of the most bitter substances in the world. It is even used as the normalizing reference index for a common bitterness index, at least accordi

> Quinine is one of the most bitter substances in the world. It is even used as the normalizing reference index for a common bitterness index, at least according to Wikipedia.[1] > In capsule form it's not used much any more for malaria because the taste of the dust on the outside of the capsule made people throw up. I would suspect that it is not used widely anymore for prophylaxis because there is chloroquine-resistant malaria parasites all over the (malarial) world.[2] The sell coated capsules, which are't bitter; these have been around for a while [3] [1] https://en.wikipedia.org/wiki/Bitterant https://en.wikipedia.org/wiki/Bitterant [2] https://www.cdc.gov/malaria/malaria_worldwide/reduction/drug_resistance.html https://www.cdc.gov/malaria/malaria_worldwide/reduction/drug... [3] https://books.google.com/books?id=AjxrAAAAMAAJ&newbks=1&newbks_redir=0&dq=chloroquine%20tablet%20coated&pg=PA1077#v=onepage https://books.google.com/books?id=AjxrAAAAMAAJ&newbks=1&newb...