3 ms·
From wikipedia. One of the most serious side effects is a toxicity in the eye (generally with chronic use).[11] People taking 400 mg of hydroxychloroquine or l
by tiredofit 7y ago
From wikipedia.
One of the most serious side effects is a toxicity in the eye (generally with chronic use).[11] People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed from one's height and weight using this calculator. Cumulative doses can also be calculated from this calculator. Macular toxicity is related to the total cumulative dose rather than the daily dose. Regular eye screening, even in the absence of visual symptoms, is recommended to begin when either of these risk factors occurs.[12]
- signa11 7y ago> ... has a cumulative dose of more than 1000 grams. ... woowza a Kg worth of drug !!! this doesn't look correct to me !
- Johnny555 7y agoPeople taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity 400mg/day for 5 years is 730 grams.
- majkinetor 7y agoonly if everything gets stored, and there is no chance for that
- Johnny555 7y agoThe risk is for cumulative (not accumulated) dose: has a cumulative dose of more than 1000 grams And the calculator they link out to gives the same number I calculated.
- reitzensteinm 7y agoA kg isn't necessarily that much over a lifetime. I'm over that with at least one drug.
- fspeech 7y agoThis drug accumulates in various tissues, so for retinopathy what matters is the cumulative amount of the drug consumed over time.
- signa11 7y agooh man ! just like excess of vitamin-d can lead to vitamin-d toxicity, so can this. in my naïveté, i was assuming that excess of it would be just flushed out.
- deleted 7y ago[deleted]
- fspeech 7y agoIts concentration in lung can be 100 times or more of that in serum. This may be helpful for its efficacy against the virus.
- javiermares 7y agotaken over the years