4 ms·

I just recently watched an interesting video about COVID-19, Zinc and Clororquine. It explains some of the fundamentals: https://www.youtube.com/watch?v=U7F1cn

I just recently watched an interesting video about COVID-19, Zinc and Clororquine. It explains some of the fundamentals: https://www.youtube.com/watch?v=U7F1cnWup9M https://www.youtube.com/watch?v=U7F1cnWup9M

sliken 7y ago
Medcram (which is the video linked) has had some great coverage of COV19. Numbers, trends, and conclusions all backed by the original published papers. Awesome.
molmalo 7y ago
Great video, thanks for sharing!
jamesblonde 7y ago
This is a good video describing the hypothesized method of action of Chloroquine. Chloroquine opens up receptors on the cell membrane to allow Zinc to enter cells - Zinc interfers with the replication of sars-cov-2. So, take Zinc supplements to increase general Zinc levels in plasma/tissue and let in Zinc with Chloroquine. An alternative proposed method of action for Chloroquine is that it binds to proteins created by sars-cov-2 (ORF3a, ORF10, ORF8). Those ORF proteins bind to heme (red in red blood cells), preventing oxygen from being transported - https://twitter.com/davidasinclair/status/1238972082756648960 https://twitter.com/davidasinclair/status/123897208275664896... David Sinclair based his tweets on this paper: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf... But most organizations are going with the Zinc theory of Chloroquine. So take Chloroquine with Zinc supplements (France, South Korea, China are doing clinical trials). Here is a translation of a Chinese study intermediate results - no data was released, which makes some people sceptical: https://twitter.com/jim_dowling/status/1239255793171660800 https://twitter.com/jim_dowling/status/1239255793171660800 Here is a great summary of available treatments used in different countries https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_InterimGuidelines_Treatment_ENG.pdf https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_In... Although untested in-vivo, many clinicians prefer hydroxycholorquine due to its superior safety profile - and 4X better efficacy in-vivo (not in humans, in cells). I tried ordering that last week when the paper came out, not sure if i will get it, though. Chloroquine is kind of old news. There has been a lot of talk around Chloroquine, starting around 6 weeks or so ago - the UK banned export of it nearly 4 weeks ago https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/ https://www.pharmaceutical-technology.com/comment/parallel-e.... I managed to order some before that. References: "Chloroquine Is a Zinc Ionophore" https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109180 https://journals.plos.org/plosone/article?id=10.1371/journal...
hydroreadsstuff 7y ago
The next episode 35 has some more infos on it, as well.

sliken 7y ago

Medcram (which is the video linked) has had some great coverage of COV19. Numbers, trends, and conclusions all backed by the original published papers. Awesome.

molmalo 7y ago

Great video, thanks for sharing!

jamesblonde 7y ago

This is a good video describing the hypothesized method of action of Chloroquine. Chloroquine opens up receptors on the cell membrane to allow Zinc to enter cells - Zinc interfers with the replication of sars-cov-2. So, take Zinc supplements to increase general Zinc levels in plasma/tissue and let in Zinc with Chloroquine. An alternative proposed method of action for Chloroquine is that it binds to proteins created by sars-cov-2 (ORF3a, ORF10, ORF8). Those ORF proteins bind to heme (red in red blood cells), preventing oxygen from being transported - https://twitter.com/davidasinclair/status/1238972082756648960 https://twitter.com/davidasinclair/status/123897208275664896... David Sinclair based his tweets on this paper: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf... But most organizations are going with the Zinc theory of Chloroquine. So take Chloroquine with Zinc supplements (France, South Korea, China are doing clinical trials). Here is a translation of a Chinese study intermediate results - no data was released, which makes some people sceptical: https://twitter.com/jim_dowling/status/1239255793171660800 https://twitter.com/jim_dowling/status/1239255793171660800 Here is a great summary of available treatments used in different countries https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_InterimGuidelines_Treatment_ENG.pdf https://epidemio.wiv-isp.be/ID/Documents/Covid19/COVID-19_In... Although untested in-vivo, many clinicians prefer hydroxycholorquine due to its superior safety profile - and 4X better efficacy in-vivo (not in humans, in cells). I tried ordering that last week when the paper came out, not sure if i will get it, though. Chloroquine is kind of old news. There has been a lot of talk around Chloroquine, starting around 6 weeks or so ago - the UK banned export of it nearly 4 weeks ago https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/ https://www.pharmaceutical-technology.com/comment/parallel-e.... I managed to order some before that. References: "Chloroquine Is a Zinc Ionophore" https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109180 https://journals.plos.org/plosone/article?id=10.1371/journal...

hydroreadsstuff 7y ago

The next episode 35 has some more infos on it, as well.