3 ms·

> allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm") Citation requested, that cytokine storms are a

by ethbro 7y ago

> allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm") Citation requested, that cytokine storms are a common pathology associated with Covid-19. Because (a) I haven't seen that in the literature, & (b) it's at odds with the published age-banded mortality rates.

tlb 7y ago
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... Not common but very serious.
WilsonPaige 7y ago
Heard of Google, bro? It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm". Always like to lead off with a lancet article, to lance the boil: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... https://link.springer.com/article/10.1007/s00134-020-05991-x https://link.springer.com/article/10.1007/s00134-020-05991-x https://www.cusabio.com/COVID-19-Cytokine-Storm https://www.cusabio.com/COVID-19-Cytokine-Storm https://lab-a-porter.com/2020/02/wuhan-coronavirus-and-cytokine-storm/ https://lab-a-porter.com/2020/02/wuhan-coronavirus-and-cytok... The age-banded mortality rates aren't all they're bandied up to be, eh? Heh, heh!
- nl 7y ago
  It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm". This just isn't true. It maybe true for a subset of patients in some circumstances. To quote your first link: Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome.
  - WilsonPaige 7y ago
    Explained by espiratory physician John Wilson in the article "Coronavirus: what happens to people's lungs when they get Covid-19?" https://www.theguardian.com/world/2020/mar/20/coronavirus-what-happens-to-peoples-lungs-when-they-get-covid-19 https://www.theguardian.com/world/2020/mar/20/coronavirus-wh... "How does the pneumonia develop? When people with Covid-19 develop a cough and fever, Wilson says this is a result of the infection reaching the respiratory tree – the air passages that conduct air between the lungs and the outside. He says: “The lining of the respiratory tree becomes injured, causing inflammation. This in turn irritates the nerves in the lining of the airway. Just a speck of dust can stimulate a cough. “But if this gets worse, it goes past just the lining of the airway and goes to the gas exchange units, which are at the end of the air passages. “If they become infected they respond by pouring out inflammatory material into the air sacs that are at the bottom of our lungs.” If the air sacs then become inflamed, Wilson says this causes an “outpouring of inflammatory material [fluid and inflammatory cells] into the lungs and we end up with pneumonia.” He says lungs that become filled with inflammatory material are unable to get enough oxygen to the bloodstream, reducing the body’s ability to take on oxygen and get rid of carbon dioxide. “That’s the usual cause of death with severe pneumonia,” he says. " The last 3 paragraphs are a description of the "cytokine storm".
drewmol 7y ago
"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients." [0]https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998 https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
IAmEveryone 7y ago
For reasons beyond my understanding, the internet (or maybe just HN) has been in love with cytokines storms for a decade or so. Far more than warranted by the actual significance of the phenomenon relative to others. It’s like quicksand in 19th century pop culture.

by ethbro 7y ago

tlb 7y ago

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... Not common but very serious.

WilsonPaige 7y ago

Heard of Google, bro? It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm". Always like to lead off with a lancet article, to lance the boil: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... https://link.springer.com/article/10.1007/s00134-020-05991-x https://link.springer.com/article/10.1007/s00134-020-05991-x https://www.cusabio.com/COVID-19-Cytokine-Storm https://www.cusabio.com/COVID-19-Cytokine-Storm https://lab-a-porter.com/2020/02/wuhan-coronavirus-and-cytokine-storm/ https://lab-a-porter.com/2020/02/wuhan-coronavirus-and-cytok... The age-banded mortality rates aren't all they're bandied up to be, eh? Heh, heh!

nl 7y ago
It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm". This just isn't true. It maybe true for a subset of patients in some circumstances. To quote your first link: Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome.
- WilsonPaige 7y ago
  Explained by espiratory physician John Wilson in the article "Coronavirus: what happens to people's lungs when they get Covid-19?" https://www.theguardian.com/world/2020/mar/20/coronavirus-what-happens-to-peoples-lungs-when-they-get-covid-19 https://www.theguardian.com/world/2020/mar/20/coronavirus-wh... "How does the pneumonia develop? When people with Covid-19 develop a cough and fever, Wilson says this is a result of the infection reaching the respiratory tree – the air passages that conduct air between the lungs and the outside. He says: “The lining of the respiratory tree becomes injured, causing inflammation. This in turn irritates the nerves in the lining of the airway. Just a speck of dust can stimulate a cough. “But if this gets worse, it goes past just the lining of the airway and goes to the gas exchange units, which are at the end of the air passages. “If they become infected they respond by pouring out inflammatory material into the air sacs that are at the bottom of our lungs.” If the air sacs then become inflamed, Wilson says this causes an “outpouring of inflammatory material [fluid and inflammatory cells] into the lungs and we end up with pneumonia.” He says lungs that become filled with inflammatory material are unable to get enough oxygen to the bloodstream, reducing the body’s ability to take on oxygen and get rid of carbon dioxide. “That’s the usual cause of death with severe pneumonia,” he says. " The last 3 paragraphs are a description of the "cytokine storm".

drewmol 7y ago

"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients." [0]https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998 https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

IAmEveryone 7y ago

For reasons beyond my understanding, the internet (or maybe just HN) has been in love with cytokines storms for a decade or so. Far more than warranted by the actual significance of the phenomenon relative to others. It’s like quicksand in 19th century pop culture.