4 ms·

I’m a bit confused why would an anti-parasite drug be used now for covid-19

by rblatz 7y ago

a3n 7y ago
They're looking at it.
CrazyStat 7y ago
There is some evidence supporting its use, e.g. https://www.ncbi.nlm.nih.gov/m/pubmed/32150618/ https://www.ncbi.nlm.nih.gov/m/pubmed/32150618/
Amygaz 7y ago
It should help alleviating the symptoms, but is in no way a antiviral. There's a phase 3 trial for treating pneumonia associated with coronavirus. This is based on prior work showing anti-inflammatory response in rheumatoid arthritis (https://www.ncbi.nlm.nih.gov/pubmed/8278823 https://www.ncbi.nlm.nih.gov/pubmed/8278823). Note that the trial is happening in China (https://clinicaltrials.gov/ct2/show/NCT04261517 https://clinicaltrials.gov/ct2/show/NCT04261517), where the barriers of entry and approval are quite low.
- mirimir 7y ago
  > After randomization, subjects take hydroxychloroquine 400mg per day for 5 days, also take conventional treatments. Huh. I'm on 200mg/day for rheumatoid arthritis. I wonder if I ought to double dose for a while.
  - Amygaz 7y ago
    Sorry for the late reply: I don't see how it would prevent infection. It could be useful post-infection, to prevent complications and inflammation. Compared that with the standard of care right now which is simply observing the patient during their recovering. There are a fair amount of studies who took the initial in vitro results (i.e. cell culture) suggesting non-specific antiviral activity (at that level coca-cola is also an antiviral, antimicrobial, and antitumoral, by the way), into animal or human, and they just did not pan out, because it isn't an antiviral.
    - mirimir 7y ago
      Thank you. I'll ask my rheumatologist about increasing the dose. In case I get infected, have trouble breathing, and can't get hospital care.
sneak 7y ago
There is some evidence it may be useful as a prophylactic to prevent infection, and it is presently undergoing trials. More reading: https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.recipharm.com/press/recipharm-notes-increased-demand-chloroquine-phosphate https://www.recipharm.com/press/recipharm-notes-increased-de... https://www.elsevier.com/__data/assets/pdf_file/0007/988648/COVID-19-Drug-Therapy_Mar-2020.pdf https://www.elsevier.com/__data/assets/pdf_file/0007/988648/... https://clinicaltrials.gov/ct2/show/NCT04303507 https://clinicaltrials.gov/ct2/show/NCT04303507 https://www.pharmacytimes.com/news/potential-pipeline-medications-for-the-coronavirus https://www.pharmacytimes.com/news/potential-pipeline-medica... https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/ https://www.pharmaceutical-technology.com/comment/parallel-e...

I’m a bit confused why would an anti-parasite drug be used now for covid-19

by rblatz 7y ago

I’m a bit confused why would an anti-parasite drug be used now for covid-19

a3n 7y ago

They're looking at it.

CrazyStat 7y ago

There is some evidence supporting its use, e.g. https://www.ncbi.nlm.nih.gov/m/pubmed/32150618/ https://www.ncbi.nlm.nih.gov/m/pubmed/32150618/

Amygaz 7y ago

It should help alleviating the symptoms, but is in no way a antiviral. There's a phase 3 trial for treating pneumonia associated with coronavirus. This is based on prior work showing anti-inflammatory response in rheumatoid arthritis (https://www.ncbi.nlm.nih.gov/pubmed/8278823 https://www.ncbi.nlm.nih.gov/pubmed/8278823). Note that the trial is happening in China (https://clinicaltrials.gov/ct2/show/NCT04261517 https://clinicaltrials.gov/ct2/show/NCT04261517), where the barriers of entry and approval are quite low.

mirimir 7y ago
> After randomization, subjects take hydroxychloroquine 400mg per day for 5 days, also take conventional treatments. Huh. I'm on 200mg/day for rheumatoid arthritis. I wonder if I ought to double dose for a while.
- Amygaz 7y ago
  Sorry for the late reply: I don't see how it would prevent infection. It could be useful post-infection, to prevent complications and inflammation. Compared that with the standard of care right now which is simply observing the patient during their recovering. There are a fair amount of studies who took the initial in vitro results (i.e. cell culture) suggesting non-specific antiviral activity (at that level coca-cola is also an antiviral, antimicrobial, and antitumoral, by the way), into animal or human, and they just did not pan out, because it isn't an antiviral.
  - mirimir 7y ago
    Thank you. I'll ask my rheumatologist about increasing the dose. In case I get infected, have trouble breathing, and can't get hospital care.

sneak 7y ago

There is some evidence it may be useful as a prophylactic to prevent infection, and it is presently undergoing trials. More reading: https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.recipharm.com/press/recipharm-notes-increased-demand-chloroquine-phosphate https://www.recipharm.com/press/recipharm-notes-increased-de... https://www.elsevier.com/__data/assets/pdf_file/0007/988648/COVID-19-Drug-Therapy_Mar-2020.pdf https://www.elsevier.com/__data/assets/pdf_file/0007/988648/... https://clinicaltrials.gov/ct2/show/NCT04303507 https://clinicaltrials.gov/ct2/show/NCT04303507 https://www.pharmacytimes.com/news/potential-pipeline-medications-for-the-coronavirus https://www.pharmacytimes.com/news/potential-pipeline-medica... https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/ https://www.pharmaceutical-technology.com/comment/parallel-e...