5 ms·

Chloroquine: An Effective Treatment for Coronavirus

34 points by KoftaBob 7y ago

minimaxir 7y ago
This URL is receiving attention because it was shared by Elon Musk on Twitter: https://twitter.com/elonmusk/status/1239650597906898947 https://twitter.com/elonmusk/status/1239650597906898947 (A reminder that Musk is not an expert on virology.)
Merrill 7y ago
Chloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting (COPCOV) Sponsor: University of Oxford The study is a double-blind, randomised, placebo-controlled trial that will be conducted in health care settings. After obtaining fully informed consent, the investigator will recruit healthcare workers, or other individuals at significant risk who can be followed reliably for 5 months. 10,000 participants will be recruited and the investigator predict an average of 200 participants per site in 50 sites. https://clinicaltrials.gov/ct2/show/NCT04303507 https://clinicaltrials.gov/ct2/show/NCT04303507 UK bans parallel export and hoarding of three Covid-19 drugs By GlobalData Healthcare SHARE The UK government has banned the parallel export and “hoarding” of three drugs being used to treat coronavirus patients in China in anticipation of shortages in Britain following the Covid-19 pandemic. The export of the US-based AbbVie’s Kaletra / Aluvia, a combination lopinavir and ritonavir, the generic drug chloroquine phosphate and the generic drug hydroxychloroquine is being restricted to meet the needs of UK patients, the government said. Hydroxychloroquine was placed on the restricted list from 14 March and Kaletra and chloroquine phosphate were added on 26 February. https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/ https://www.pharmaceutical-technology.com/comment/parallel-e...
deleted 7y ago
[deleted]
WilsonPaige 7y ago
Opposing statement by a Ghanian doctor and director of public health: "Dr. Badu Sarkodie, the Director of Public Health, Ghana Health Service (GHS), says they have no evidence that Chloroquine Phosphate 250mg is an effective treatment of the flu-like coronavirus (COVID-19). He was reacting to claims on social media that Chloroquine Phosphate 250mg had been found by French and Chinese doctors to be effective for treatment of the virus. Dr. Sarkodie in an interview with the Ghana News Agency (GNA) said although the claim sounded promising, the GHS had not had any efficacy clinical trial to confirm that. They could therefore not make any recommendation for the use of the drug to treat the virus. "I cannot dispute the claim so the person saying this should provide more information because we have not sighted any publication to this effect," he added."
- sp332 7y ago
  That was two weeks ago. Now we have the results of two clinical studies.
  - deleted 7y ago
    [deleted]
  - WilsonPaige 7y ago
    Citations? That was precisely the doctor's objection - no citations, no facts, no data.
    - sp332 7y ago
      https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_article https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/... This summarizes the results of a bunch of trials that were run in parallel in China.
- rasz 7y ago
  Some random doctor from a country with 6 confirmed cases must know better than studies in China.
WilsonPaige 7y ago
Then we have a treatment (i.e., zinc gluconate + chloroquine): A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19. The covid-19 virus' usual course is to first infect the eye, nose and/or throat and then, after ~3 days, move down into the lungs. If chloroquine (mg) stops the virus in the bloodstream then the combination of (dissolved zinc in mouth + chloroquine pill (up to 500 mg of chloroquine per day) should slow (if not stop completely) the virus, allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm"). But this treatment must be done within 3-4 days of contracting covid-19. These medicines are cheaply available now.
- Engineering-MD 7y ago
  Just in case anyone gets drawn into this, all the above is not based on any evidence. The poster has literally made up a ‘protocol’ that sounds right. Chloroquine is under current investigation (ie results not yet in, and certainly not a treatment protocol) and zinc has been shown in some cases to maybe improve some aspect of illness, it’s far from proven. The rest of what they said is at best speculation/conjecture.
  - WilsonPaige 7y ago
    On Chloroquine phosphate: https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.ncbi.nlm.nih.gov/pubmed/32074550 DIY on zinc - There is an entire industry of antiviral zinc sprays, lozenges and pills. Zinc stops viral replication deader than your prefrontal lobes: https://duckduckgo.com/?q=zinc+halts+viral+replication&t=opera&ia=web https://duckduckgo.com/?q=zinc+halts+viral+replication&t=ope... Like I said, we have herein a safe treatment that is cheap, available, and free of risk, namely 1. immediate zinc lozenge/spray/pill dissolved in mouth to be applied early (preferably first 3 days) of illness, and possibly every day thereafter + 2.Chloroquine phosphate (up to 500 mg/day).
- jlgaddis 7y ago
  Cite your sources, please? Otherwise, I'll continue to flag posts like this.
imagetic 7y ago
https://factcheck.afp.com/chloroquine-has-not-been-approved-treatment-covid-19 https://factcheck.afp.com/chloroquine-has-not-been-approved-...
kiterunner2346 7y ago
WilsonPaige is right (if not always for the "right" reason): "Coronavirus Chloroquine & Zinc Treatment": https://citycourier.org/news/coronavirus-chloroquine-zinc-treatment/ https://citycourier.org/news/coronavirus-chloroquine-zinc-tr...
- kiterunner2346 7y ago
  Why did you delete most of wilsonpaige's posts? All he did is put two things together and come up with an idea that will apparently work. So he's kinda in Neils Bohr's situation with the hydrogen atom: it works, it only works here, I don't know why it works, but it works! Isn't that the essence of creativity? Why the dunning and shunning? If the women in reasonable shoes on this bbs had any creativity we wouldn't be in a jam with Covid. Is wilsonpaige so different in this regard from Elon Musk? Musk posts re quinone and is praised and his ideas spread. Wilsonpaige at first doubts the quinone solution, then within hours finds confirming studies, adds to it his experience with zinc antivirals and comes up with a better solution (albeit one w/o an underlying mechanism). Now you've torn his posts up and thrown them away. Shame!

34 points by KoftaBob 7y ago

This URL is receiving attention because it was shared by Elon Musk on Twitter: https://twitter.com/elonmusk/status/1239650597906898947 https://twitter.com/elonmusk/status/1239650597906898947 (A reminder that Musk is not an expert on virology.)

Merrill 7y ago

Chloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting (COPCOV) Sponsor: University of Oxford The study is a double-blind, randomised, placebo-controlled trial that will be conducted in health care settings. After obtaining fully informed consent, the investigator will recruit healthcare workers, or other individuals at significant risk who can be followed reliably for 5 months. 10,000 participants will be recruited and the investigator predict an average of 200 participants per site in 50 sites. https://clinicaltrials.gov/ct2/show/NCT04303507 https://clinicaltrials.gov/ct2/show/NCT04303507 UK bans parallel export and hoarding of three Covid-19 drugs By GlobalData Healthcare SHARE The UK government has banned the parallel export and “hoarding” of three drugs being used to treat coronavirus patients in China in anticipation of shortages in Britain following the Covid-19 pandemic. The export of the US-based AbbVie’s Kaletra / Aluvia, a combination lopinavir and ritonavir, the generic drug chloroquine phosphate and the generic drug hydroxychloroquine is being restricted to meet the needs of UK patients, the government said. Hydroxychloroquine was placed on the restricted list from 14 March and Kaletra and chloroquine phosphate were added on 26 February. https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/ https://www.pharmaceutical-technology.com/comment/parallel-e...

deleted 7y ago

[deleted]

WilsonPaige 7y ago

Opposing statement by a Ghanian doctor and director of public health: "Dr. Badu Sarkodie, the Director of Public Health, Ghana Health Service (GHS), says they have no evidence that Chloroquine Phosphate 250mg is an effective treatment of the flu-like coronavirus (COVID-19). He was reacting to claims on social media that Chloroquine Phosphate 250mg had been found by French and Chinese doctors to be effective for treatment of the virus. Dr. Sarkodie in an interview with the Ghana News Agency (GNA) said although the claim sounded promising, the GHS had not had any efficacy clinical trial to confirm that. They could therefore not make any recommendation for the use of the drug to treat the virus. "I cannot dispute the claim so the person saying this should provide more information because we have not sighted any publication to this effect," he added."

sp332 7y ago
That was two weeks ago. Now we have the results of two clinical studies.
- deleted 7y ago
  [deleted]
- WilsonPaige 7y ago
  Citations? That was precisely the doctor's objection - no citations, no facts, no data.
  - sp332 7y ago
    https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_article https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/... This summarizes the results of a bunch of trials that were run in parallel in China.
rasz 7y ago
Some random doctor from a country with 6 confirmed cases must know better than studies in China.

WilsonPaige 7y ago

Then we have a treatment (i.e., zinc gluconate + chloroquine): A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19. The covid-19 virus' usual course is to first infect the eye, nose and/or throat and then, after ~3 days, move down into the lungs. If chloroquine (mg) stops the virus in the bloodstream then the combination of (dissolved zinc in mouth + chloroquine pill (up to 500 mg of chloroquine per day) should slow (if not stop completely) the virus, allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm"). But this treatment must be done within 3-4 days of contracting covid-19. These medicines are cheaply available now.

Engineering-MD 7y ago
Just in case anyone gets drawn into this, all the above is not based on any evidence. The poster has literally made up a ‘protocol’ that sounds right. Chloroquine is under current investigation (ie results not yet in, and certainly not a treatment protocol) and zinc has been shown in some cases to maybe improve some aspect of illness, it’s far from proven. The rest of what they said is at best speculation/conjecture.
- WilsonPaige 7y ago
  On Chloroquine phosphate: https://www.ncbi.nlm.nih.gov/pubmed/32074550 https://www.ncbi.nlm.nih.gov/pubmed/32074550 DIY on zinc - There is an entire industry of antiviral zinc sprays, lozenges and pills. Zinc stops viral replication deader than your prefrontal lobes: https://duckduckgo.com/?q=zinc+halts+viral+replication&t=opera&ia=web https://duckduckgo.com/?q=zinc+halts+viral+replication&t=ope... Like I said, we have herein a safe treatment that is cheap, available, and free of risk, namely 1. immediate zinc lozenge/spray/pill dissolved in mouth to be applied early (preferably first 3 days) of illness, and possibly every day thereafter + 2.Chloroquine phosphate (up to 500 mg/day).
jlgaddis 7y ago
Cite your sources, please? Otherwise, I'll continue to flag posts like this.

imagetic 7y ago

https://factcheck.afp.com/chloroquine-has-not-been-approved-treatment-covid-19 https://factcheck.afp.com/chloroquine-has-not-been-approved-...

kiterunner2346 7y ago

WilsonPaige is right (if not always for the "right" reason): "Coronavirus Chloroquine & Zinc Treatment": https://citycourier.org/news/coronavirus-chloroquine-zinc-treatment/ https://citycourier.org/news/coronavirus-chloroquine-zinc-tr...

kiterunner2346 7y ago
Why did you delete most of wilsonpaige's posts? All he did is put two things together and come up with an idea that will apparently work. So he's kinda in Neils Bohr's situation with the hydrogen atom: it works, it only works here, I don't know why it works, but it works! Isn't that the essence of creativity? Why the dunning and shunning? If the women in reasonable shoes on this bbs had any creativity we wouldn't be in a jam with Covid. Is wilsonpaige so different in this regard from Elon Musk? Musk posts re quinone and is praised and his ideas spread. Wilsonpaige at first doubts the quinone solution, then within hours finds confirming studies, adds to it his experience with zinc antivirals and comes up with a better solution (albeit one w/o an underlying mechanism). Now you've torn his posts up and thrown them away. Shame!