2 ms·
I am skeptical of their 1mcg claim. The only way to get to 1mcg for an mRNA-based vaccine is through even newer and untested technology: self-amplifying mRNA, s
by DrAwdeOccarim 7y ago
I am skeptical of their 1mcg claim. The only way to get to 1mcg for an mRNA-based vaccine is through even newer and untested technology: self-amplifying mRNA, some undisclosed delivery technology/chemistry, or some undisclosed improvement to their adjuvanting technology. In general, they have been far behind Moderna and BioNTech for years, so I'm not sure we should be hitching our wagon to them.
This is their most recent clinical trial results (2017) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31665-3/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... showing basically failure without more-immunogenic delivery.
This is their most recent clinical publication showing their adjuvanting technology (2019) https://www.sciencedirect.com/science/article/pii/S0264410X19302191 https://www.sciencedirect.com/science/article/pii/S0264410X1... which in general is needed to make-up for their lack of potency in their mRNA vaccine technology. A problem neither BioNTech nor Moderna have with their mRNA and delivery technology.