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How about a project to understand who is NOT getting Covid-19? There are almost certainly healthcare workers in heavily infected areas who "should have gotten

How about a project to understand who is NOT getting Covid-19? There are almost certainly healthcare workers in heavily infected areas who "should have gotten it but haven't". Understanding this could rapidly lead to: - screens to identify who's vulnerable and who's not - therapeutic strategies (probably not ready for this round, but for future rounds) edit: removed errant footnote reference

thih9 7y ago
> There are almost certainly healthcare workers in heavily infected areas who "should have gotten it but haven't"[0] It looks like the link is missing. Does anyone have it?
- dnautics 7y ago
  no, sorry, I was going to add more text and put the bullets into a footnote, but went back to coding. If you would like more information on something similar, consider: https://www.theguardian.com/world/2007/may/27/aids.features https://www.theguardian.com/world/2007/may/27/aids.features The flip side of this is that I used to work in structural biology, and there were tons of structural biology grants flying around justifying studying these antibodies on the grounds that they might lead directly to vaccination strategies. Well, that is highly unlikely because some of these antibodies have a germline (versus adaptive immunity internal random generator) mutation that fundamentally changes the higher-order architecture of their antibodies that makes them not comparable to the antibodies that the rest of us have. The blatant (deliberate or brainless, I wasn't sure) mischaracterization by the PIs and the brazen funding of these proposals (deliberate or brainless, I wasn't sure) by the grant program managers that contributed me to leaving academia. I just wish they were honest and said "we are studying this because it's interesting and we would like to know more about the universe".
deleted 7y ago
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bastawhiz 7y ago
I've read multiple reports online that truvada and descocy (HIV medication sold as a prophylactic, largely to LGBT individuals) may offer some resistance to COVID-19. I think it's largely bunk speculation, but research into whether existing, mass-produced pharmaceuticals would help could be incredibly valuable.
- tjoff 7y ago
  Don't know about trubada/descocy but they are doing exactly that. Still, takes many months to get results though.

thih9 7y ago

> There are almost certainly healthcare workers in heavily infected areas who "should have gotten it but haven't"[0] It looks like the link is missing. Does anyone have it?

dnautics 7y ago
no, sorry, I was going to add more text and put the bullets into a footnote, but went back to coding. If you would like more information on something similar, consider: https://www.theguardian.com/world/2007/may/27/aids.features https://www.theguardian.com/world/2007/may/27/aids.features The flip side of this is that I used to work in structural biology, and there were tons of structural biology grants flying around justifying studying these antibodies on the grounds that they might lead directly to vaccination strategies. Well, that is highly unlikely because some of these antibodies have a germline (versus adaptive immunity internal random generator) mutation that fundamentally changes the higher-order architecture of their antibodies that makes them not comparable to the antibodies that the rest of us have. The blatant (deliberate or brainless, I wasn't sure) mischaracterization by the PIs and the brazen funding of these proposals (deliberate or brainless, I wasn't sure) by the grant program managers that contributed me to leaving academia. I just wish they were honest and said "we are studying this because it's interesting and we would like to know more about the universe".

deleted 7y ago

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bastawhiz 7y ago

I've read multiple reports online that truvada and descocy (HIV medication sold as a prophylactic, largely to LGBT individuals) may offer some resistance to COVID-19. I think it's largely bunk speculation, but research into whether existing, mass-produced pharmaceuticals would help could be incredibly valuable.

tjoff 7y ago
Don't know about trubada/descocy but they are doing exactly that. Still, takes many months to get results though.