5 ms·

Considering that lisinopril (Prinivil, Zestrel, etc, an ACE inhibitor) is, according to any list I could find, easily in the top 10 meds prescribed in the US (a

Considering that lisinopril (Prinivil, Zestrel, etc, an ACE inhibitor) is, according to any list I could find, easily in the top 10 meds prescribed in the US (and by some top three or number one), this is something that should definitely be more publicly known. I’m not saying anyone should just stop taking their hypertension drugs, that’s a horrible idea. But if you do suspect that you might have COVID-19, you should probably call your doctor - there’s no shortage of other options. One of those lists: https://www.medicinenet.com/top_drugs_prescribed_in_the_us/views.htm https://www.medicinenet.com/top_drugs_prescribed_in_the_us/v...

FeteCommuniste 7y ago
A virologist gives a different view in this thread: https://twitter.com/angie_rasmussen/status/1238946940882006016 https://twitter.com/angie_rasmussen/status/12389469408820060... Btw, ACE2 expression is decreased in unmedicated diabetics and HTN patients and the elderly which would imply that those groups should have some degree of protection from the virus (ceteris paribus, obviously). In fact that seems to be exactly the opposite of what we see. Some research even indicates that ACE2 could help prevent ARDS-induced lung injury: https://www.nature.com/articles/srep27911 https://www.nature.com/articles/srep27911 But in that article the injury wasn't induced by COVID-19 so really we don't know enough yet. (Ref. for decreased ACE2 expression in diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/)
ianai 7y ago
It is widely known (to some extent) that preexisting conditions severely contribute to the harm of covid-19.
snapetom 7y ago
ACE != ACE2. ACE inhibitors have no effect on ACE2. https://www.nrcresearchpress.com/doi/10.1139/y02-021 https://www.nrcresearchpress.com/doi/10.1139/y02-021
- mikedilger 7y ago
  https://www.researchgate.net/publication/26859747_Upregulation_of_angiotensin-converting_enzyme_ACE_2_in_hepatic_fibrosis_by_ACE_inhibitors https://www.researchgate.net/publication/26859747_Upregulati... "Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors"

FeteCommuniste 7y ago

A virologist gives a different view in this thread: https://twitter.com/angie_rasmussen/status/1238946940882006016 https://twitter.com/angie_rasmussen/status/12389469408820060... Btw, ACE2 expression is decreased in unmedicated diabetics and HTN patients and the elderly which would imply that those groups should have some degree of protection from the virus (ceteris paribus, obviously). In fact that seems to be exactly the opposite of what we see. Some research even indicates that ACE2 could help prevent ARDS-induced lung injury: https://www.nature.com/articles/srep27911 https://www.nature.com/articles/srep27911 But in that article the injury wasn't induced by COVID-19 so really we don't know enough yet. (Ref. for decreased ACE2 expression in diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/)

ianai 7y ago

It is widely known (to some extent) that preexisting conditions severely contribute to the harm of covid-19.

snapetom 7y ago

ACE != ACE2. ACE inhibitors have no effect on ACE2. https://www.nrcresearchpress.com/doi/10.1139/y02-021 https://www.nrcresearchpress.com/doi/10.1139/y02-021

mikedilger 7y ago
https://www.researchgate.net/publication/26859747_Upregulation_of_angiotensin-converting_enzyme_ACE_2_in_hepatic_fibrosis_by_ACE_inhibitors https://www.researchgate.net/publication/26859747_Upregulati... "Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors"