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From the article: "ACE2 can also be increased by thiazolidinediones and ibuprofen. These data suggest that ACE2 expression is increased in diabetes and treatmen

From the article: "ACE2 can also be increased by thiazolidinediones and ibuprofen. These data suggest that ACE2 expression is increased in diabetes and treatment with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with COVID-19. We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19."

chrismeller 7y ago
Considering that lisinopril (Prinivil, Zestrel, etc, an ACE inhibitor) is, according to any list I could find, easily in the top 10 meds prescribed in the US (and by some top three or number one), this is something that should definitely be more publicly known. I’m not saying anyone should just stop taking their hypertension drugs, that’s a horrible idea. But if you do suspect that you might have COVID-19, you should probably call your doctor - there’s no shortage of other options. One of those lists: https://www.medicinenet.com/top_drugs_prescribed_in_the_us/views.htm https://www.medicinenet.com/top_drugs_prescribed_in_the_us/v...
- FeteCommuniste 7y ago
  A virologist gives a different view in this thread: https://twitter.com/angie_rasmussen/status/1238946940882006016 https://twitter.com/angie_rasmussen/status/12389469408820060... Btw, ACE2 expression is decreased in unmedicated diabetics and HTN patients and the elderly which would imply that those groups should have some degree of protection from the virus (ceteris paribus, obviously). In fact that seems to be exactly the opposite of what we see. Some research even indicates that ACE2 could help prevent ARDS-induced lung injury: https://www.nature.com/articles/srep27911 https://www.nature.com/articles/srep27911 But in that article the injury wasn't induced by COVID-19 so really we don't know enough yet. (Ref. for decreased ACE2 expression in diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/)
- ianai 7y ago
  It is widely known (to some extent) that preexisting conditions severely contribute to the harm of covid-19.
- snapetom 7y ago
  ACE != ACE2. ACE inhibitors have no effect on ACE2. https://www.nrcresearchpress.com/doi/10.1139/y02-021 https://www.nrcresearchpress.com/doi/10.1139/y02-021
  - mikedilger 7y ago
    https://www.researchgate.net/publication/26859747_Upregulation_of_angiotensin-converting_enzyme_ACE_2_in_hepatic_fibrosis_by_ACE_inhibitors https://www.researchgate.net/publication/26859747_Upregulati... "Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors"
wolfi1 7y ago
are those ACE inhibitors also prescribed in China? I really doubt that
- pkaye 7y ago
  Why do you doubt they are prescribed in China?
- onetimemanytime 7y ago
  any reason to doubt it? I mean they are made of flesh and blood as well.
  - wolfi1 7y ago
    hypertension is a western disease

chrismeller 7y ago

Considering that lisinopril (Prinivil, Zestrel, etc, an ACE inhibitor) is, according to any list I could find, easily in the top 10 meds prescribed in the US (and by some top three or number one), this is something that should definitely be more publicly known. I’m not saying anyone should just stop taking their hypertension drugs, that’s a horrible idea. But if you do suspect that you might have COVID-19, you should probably call your doctor - there’s no shortage of other options. One of those lists: https://www.medicinenet.com/top_drugs_prescribed_in_the_us/views.htm https://www.medicinenet.com/top_drugs_prescribed_in_the_us/v...

FeteCommuniste 7y ago
A virologist gives a different view in this thread: https://twitter.com/angie_rasmussen/status/1238946940882006016 https://twitter.com/angie_rasmussen/status/12389469408820060... Btw, ACE2 expression is decreased in unmedicated diabetics and HTN patients and the elderly which would imply that those groups should have some degree of protection from the virus (ceteris paribus, obviously). In fact that seems to be exactly the opposite of what we see. Some research even indicates that ACE2 could help prevent ARDS-induced lung injury: https://www.nature.com/articles/srep27911 https://www.nature.com/articles/srep27911 But in that article the injury wasn't induced by COVID-19 so really we don't know enough yet. (Ref. for decreased ACE2 expression in diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992757/)
ianai 7y ago
It is widely known (to some extent) that preexisting conditions severely contribute to the harm of covid-19.
snapetom 7y ago
ACE != ACE2. ACE inhibitors have no effect on ACE2. https://www.nrcresearchpress.com/doi/10.1139/y02-021 https://www.nrcresearchpress.com/doi/10.1139/y02-021
- mikedilger 7y ago
  https://www.researchgate.net/publication/26859747_Upregulation_of_angiotensin-converting_enzyme_ACE_2_in_hepatic_fibrosis_by_ACE_inhibitors https://www.researchgate.net/publication/26859747_Upregulati... "Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors"

wolfi1 7y ago

are those ACE inhibitors also prescribed in China? I really doubt that

pkaye 7y ago
Why do you doubt they are prescribed in China?
onetimemanytime 7y ago
any reason to doubt it? I mean they are made of flesh and blood as well.
- wolfi1 7y ago
  hypertension is a western disease