There's been a lot of work done on alternate biochemistries. Most of the alternate chemistries that look practical are at low temperatures, not high ones, becau

There's been a lot of work done on alternate biochemistries. Most of the alternate chemistries that look practical are at low temperatures, not high ones, because high temperatures inherently break down complex molecules. See https://en.wikipedia.org/wiki/Hypothetical_types_of_biochemistry https://en.wikipedia.org/wiki/Hypothetical_types_of_biochemi..., or look up Cronin's work on metal-based self-replicating structures.